| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TLK1 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 11314006 | SIGNOR-107037 |
| RPS6KA3 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 10464286 | SIGNOR-70436 |
| TGM2 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 16407273 | SIGNOR-143642 |
| AURKB | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 14583461 | SIGNOR-118894 |
| RPS6KA5 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 15994958 | SIGNOR-138483 |
| PBK | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 16982762 | SIGNOR-149716 |
| AURKA | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 12234980 | SIGNOR-118886 |
| AURKB | H3C1 | Ser29 | ATKAARKsAPATGGV | phosphorylation down-regulates activity | 11856369 | SIGNOR-114852 |
| RPS6KA5 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 10464286 | SIGNOR-70444 |
| RPS6KA5 | H3C1 | Ser29 | ATKAARKsAPATGGV | phosphorylation down-regulates activity | 20129940 | SIGNOR-163712 |
| HASPIN | H3C1 | Thr3 | T-->R | phosphorylation up-regulates activity | 20705812 | SIGNOR-275418 |
| VRK1 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 17938195 | SIGNOR-158436 |
| AURKB | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 12588998 | SIGNOR-98297 |
| PRKCD | H3C1 | Thr46 | PHRYRPGtVALREIR | phosphorylation up-regulates activity | 19363025 | SIGNOR-185144 |
| PIM | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 17643117 | SIGNOR-259409 |
| HASPIN | H3C1 | Thr4 | tKQTARKS | phosphorylation up-regulates activity | 20705812 | SIGNOR-275428 |
| RPS6KA3 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 15994958 | SIGNOR-138475 |
| MAPK14 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 20626350 | SIGNOR-166602 |
| RPS6KA5 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 14625384 | SIGNOR-119237 |
| AURKC | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 12588998 | SIGNOR-98361 |
| RPS6KA3 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 14625384 | SIGNOR-119229 |
| CKM complex | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273170 |
| CDK8 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273171 |
| PAK1 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 12151336 | SIGNOR-91050 |
| AURKB | H3C1 | Ser29 | ATKAARKsAPATGGV | phosphorylation down-regulates activity | 21282660 | SIGNOR-171717 |
| AURKA | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 12588998 | SIGNOR-98289 |
| PIM1 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 17643117 | SIGNOR-156946 |
| AURKC | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 14583461 | SIGNOR-118898 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TLK1 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation up-regulates → | H3C1 | 11314006 | SIGNOR-107037 |
| RPS6KA3 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 10464286 | SIGNOR-70436 |
| TGM2 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 16407273 | SIGNOR-143642 |
| AURKB | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation up-regulates → | H3C1 | 14583461 | SIGNOR-118894 |
| RPS6KA5 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 15994958 | SIGNOR-138483 |
| PBK | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 16982762 | SIGNOR-149716 |
| AURKA | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 12234980 | SIGNOR-118886 |
| AURKB | phosphorylation up-regulates → | H3C1 PSer29 | phosphorylation down-regulates ⊣ | H3C1 | 11856369 | SIGNOR-114852 |
| RPS6KA5 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 10464286 | SIGNOR-70444 |
| RPS6KA5 | phosphorylation up-regulates → | H3C1 PSer29 | phosphorylation down-regulates ⊣ | H3C1 | 20129940 | SIGNOR-163712 |
| HASPIN | phosphorylation up-regulates → | H3C1 PThr3 | phosphorylation up-regulates → | H3C1 | 20705812 | SIGNOR-275418 |
| VRK1 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 17938195 | SIGNOR-158436 |
| AURKB | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation up-regulates → | H3C1 | 12588998 | SIGNOR-98297 |
| PRKCD | phosphorylation up-regulates → | H3C1 PThr46 | phosphorylation up-regulates → | H3C1 | 19363025 | SIGNOR-185144 |
| PIM | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 17643117 | SIGNOR-259409 |
| HASPIN | phosphorylation up-regulates → | H3C1 PThr4 | phosphorylation up-regulates → | H3C1 | 20705812 | SIGNOR-275428 |
| RPS6KA3 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 15994958 | SIGNOR-138475 |
| MAPK14 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 20626350 | SIGNOR-166602 |
| RPS6KA5 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 14625384 | SIGNOR-119237 |
| AURKC | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation up-regulates → | H3C1 | 12588998 | SIGNOR-98361 |
| RPS6KA3 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 14625384 | SIGNOR-119229 |
| CKM complex | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 18418385 | SIGNOR-273170 |
| CDK8 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 18418385 | SIGNOR-273171 |
| PAK1 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 12151336 | SIGNOR-91050 |
| AURKB | phosphorylation up-regulates → | H3C1 PSer29 | phosphorylation down-regulates ⊣ | H3C1 | 21282660 | SIGNOR-171717 |
| AURKA | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation up-regulates → | H3C1 | 12588998 | SIGNOR-98289 |
| PIM1 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 17643117 | SIGNOR-156946 |
| AURKC | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation up-regulates → | H3C1 | 14583461 | SIGNOR-118898 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TLK1 | phosphorylation → up-regulates activity | H3C1 | SIGNOR-107037 |
| RPS6KA3 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-70436 |
| TGM2 | phosphorylation → unknown | H3C1 | SIGNOR-143642 |
| AURKB | phosphorylation → up-regulates activity | H3C1 | SIGNOR-118894 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-138483 |
| PBK | phosphorylation → unknown | H3C1 | SIGNOR-149716 |
| AURKA | phosphorylation → unknown | H3C1 | SIGNOR-118886 |
| AURKB | phosphorylation → down-regulates activity | H3C1 | SIGNOR-114852 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-70444 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-163712 |
| HASPIN | phosphorylation → up-regulates activity | H3C1 | SIGNOR-275418 |
| VRK1 | phosphorylation → unknown | H3C1 | SIGNOR-158436 |
| AURKB | phosphorylation → up-regulates activity | H3C1 | SIGNOR-98297 |
| PRKCD | phosphorylation → up-regulates activity | H3C1 | SIGNOR-185144 |
| PIM | phosphorylation → down-regulates activity | H3C1 | SIGNOR-259409 |
| HASPIN | phosphorylation → up-regulates activity | H3C1 | SIGNOR-275428 |
| RPS6KA3 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-138475 |
| MAPK14 | phosphorylation → unknown | H3C1 | SIGNOR-166602 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-119237 |
| AURKC | phosphorylation → up-regulates activity | H3C1 | SIGNOR-98361 |
| RPS6KA3 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-119229 |
| CKM complex | phosphorylation → down-regulates activity | H3C1 | SIGNOR-273170 |
| CDK8 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-273171 |
| PAK1 | phosphorylation → unknown | H3C1 | SIGNOR-91050 |
| AURKB | phosphorylation → down-regulates activity | H3C1 | SIGNOR-171717 |
| AURKA | phosphorylation → up-regulates activity | H3C1 | SIGNOR-98289 |
| PIM1 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-156946 |
| AURKC | phosphorylation → up-regulates activity | H3C1 | SIGNOR-118898 |
