| Name | PRKDC |
| ID | P78527 |
| Role | kinase |
| Enzymatic Domains |
FAT 2906-3539 PROSITE-ProRule
PI3K/PI4K catalytic 3722-4053 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | POLL | Thr204 | EASDGEEtQVSAADL | phosphorylation up-regulates activity | 28109743 | SIGNOR-273835 |
| PRKDC | POU2F1 | Thr226 | LQAQNLLtQLPQQSQ | phosphorylation down-regulates | 9368058 | SIGNOR-53262 |
| PRKDC | PLK1 | – | phosphorylation up-regulates activity | 25925375 | SIGNOR-279562 | |
| PRKDC | KAT2B | – | phosphorylation up-regulates activity | 28854354 | SIGNOR-280092 | |
| PRKDC | PARP1 | – | phosphorylation down-regulates activity | 22504299 | SIGNOR-280093 | |
| PRKDC | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates | 15668230 | SIGNOR-133384 |
| PRKDC | SRF | Ser435 | LTVLNAFsQAPSTMQ | phosphorylation up-regulates activity | 8407951 | SIGNOR-248921 |
| PRKDC | IRF3 | Thr135 | GGGSTSDtQEDILDE | phosphorylation up-regulates | 11867762 | SIGNOR-115331 |
| PRKDC | WRN | Ser467 | DTSYVIEsDEDLEME | phosphorylation up-regulates | 24429382 | SIGNOR-203741 |
| PRKDC | GOLPH3 | Thr148 | KETQPPEtVQNWIEL | phosphorylation up-regulates activity | 24485452 | SIGNOR-253558 |
| PRKDC | FH | Thr236 | IKIGRTHtQDAVPLT | phosphorylation up-regulates activity | 26237645 | SIGNOR-266349 |
| PRKDC | RPA2 | Ser33 | GFGSPAPsQAEKKSR | phosphorylation unknown | 9139719 | SIGNOR-248971 |
| PRKDC | PPARGC1A | Ser636 | SRRPRYDsYEEYQHE | phosphorylation down-regulates quantity by destabilization | 36696363 | SIGNOR-277911 |
| PRKDC | PRKDC | Ser2624 | QTRTQEGsLSARWPV | phosphorylation up-regulates activity | 12186630 | SIGNOR-249156 |
| PRKDC | PNKP | Ser114 | EETRTPEsQPDTPPG | phosphorylation up-regulates | 21824916 | SIGNOR-176016 |
| PRKDC | XRCC6 | Ser27 | QEENLEAsGDYKYSG | phosphorylation up-regulates activity | 26337656 | SIGNOR-274022 |
| PRKDC | WRN | Ser440 | DTSYVIEsDEDLEME | phosphorylation up-regulates | 24429382 | SIGNOR-203737 |
| PRKDC | PRKDC | Ser2056 | VQSYSYSsQDPRPAT | phosphorylation up-regulates | 17189255 | SIGNOR-151445 |
| PRKDC | PNPT1 | Ser776 | IVMGEPIsQSSSNSQ | phosphorylation up-regulates activity | 22815474 | SIGNOR-263182 |
| PRKDC | HNRNPU | Ser59 | AMEPGNGsLDLGGDS | phosphorylation up-regulates | 19351595 | SIGNOR-185058 |
| PRKDC | PRKDC | Thr2609 | LTPMFVEtQASQGTL | phosphorylation up-regulates activity | 12186630 | SIGNOR-249154 |
| PRKDC | HSP90AA1 | Thr5 | tQTQDQPM | phosphorylation unknown | 2507541 | SIGNOR-248887 |
| PRKDC | RPA2 | Ser13 | FESYGSSsYGGAGGY | phosphorylation down-regulates activity | 9295339 | SIGNOR-248982 |
| PRKDC | XRCC4 | Ser328 | LETLRNSsPEDLFDE | phosphorylation up-regulates activity | 26774286 | SIGNOR-277199 |
| PRKDC | XRCC6 | Ser33 | ASGDYKYsGRDSLIF | phosphorylation up-regulates activity | 26337656 | SIGNOR-274023 |
| PRKDC | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 18439899 | SIGNOR-252431 |
| PRKDC | RPA2 | Ser12 | GFESYGSsSYGGAGG | phosphorylation down-regulates activity | 9295339 | SIGNOR-248981 |
| PRKDC | GOLPH3 | Thr143 | ALKHVKEtQPPETVQ | phosphorylation up-regulates activity | 24485452 | SIGNOR-253557 |
| PRKDC | POU2F1 | Ser232 | LTQLPQQsQANLLQS | phosphorylation down-regulates | 9368058 | SIGNOR-53258 |
| PRKDC | RPA2 | Ser11 | SGFESYGsSSYGGAG | phosphorylation down-regulates activity | 9295339 | SIGNOR-248980 |
| PRKDC | H1-2 | Thr146 | KKAAGGAtPKKSAKK | phosphorylation down-regulates activity | 22249259 | SIGNOR-273834 |
| PRKDC | PRKAG1 | Ser192 | KPEFMSKsLEELQIG | phosphorylation up-regulates activity | 31983282 | SIGNOR-277503 |
| PRKDC | NHEJ1 | Ser245 | PHTSNSAsLQGIDSQ | phosphorylation unknown | 18644470 | SIGNOR-179532 |
| PRKDC | YBX1 | Thr89 | EDVFVHQtAIKKNNP | phosphorylation up-regulates activity | 36475703 | SIGNOR-277611 |
| PRKDC | DCLRE1C | Ser516 | SSTVAGGsQSPKLFS | phosphorylation up-regulates | 16600297 | SIGNOR-145837 |
| PRKDC | MCC | Ser118 | SELRSELsQSQHEVN | phosphorylation up-regulates activity | 21779472 | SIGNOR-273530 |
| PRKDC | TOP1 | Ser10 | GDHLHNDsQIEADFR | phosphorylation down-regulates quantity by destabilization | 28415827 | SIGNOR-277352 |
| PRKDC | PRKDC | Ser2612 | MFVETQAsQGTLQTR | phosphorylation up-regulates activity | 12186630 | SIGNOR-249155 |
| PRKDC | RPA2 | Thr21 | YGGAGGYtQSPGGFG | phosphorylation unknown | 14872059 | SIGNOR-121873 |
| PRKDC | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates quantity by stabilization | 20219974 | SIGNOR-279561 |
| PRKDC | NR3C1 | Ser508 | QQATTGVsQETSENP | phosphorylation unknown | 9038175 | SIGNOR-248965 |
| PRKDC | PRKDC | Thr2638 | VAGQIRAtQQQHDFT | phosphorylation up-regulates activity | 12186630 | SIGNOR-249159 |
| PRKDC | PRKAG1 | Thr284 | LKCYLHEtLETIINR | phosphorylation up-regulates activity | 31983282 | SIGNOR-277504 |
| PRKDC | MITF | Ser431 | S-->C | phosphorylation up-regulates activity | 38316520 | SIGNOR-277899 |
| PRKDC | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 9363941 | SIGNOR-53030 |
| PRKDC | PRKDC | Thr3950 | GHAFGSAtQFLPVPE | phosphorylation down-regulates | 17189255 | SIGNOR-151453 |
| PRKDC | XRCC4 | Ser327 | SLETLRNsSPEDLFD | phosphorylation up-regulates activity | 26774286 | SIGNOR-277198 |
| PRKDC | DCLRE1C | Ser503 | NDEITDEsLENFPSS | phosphorylation up-regulates | 16874298 | SIGNOR-148327 |
| PRKDC | TDP1 | Ser81 | PKRQKSGsQEDLGWC | phosphorylation up-regulates | 19851285 | SIGNOR-188776 |
| PRKDC | SRF | Ser446 | STMQVSHsQVQEPGG | phosphorylation up-regulates activity | 8407951 | SIGNOR-248922 |
| PRKDC | ATM | Ser1987 | GSQSTTIsSLSEKSK | phosphorylation down-regulates activity | 32832608 | SIGNOR-278324 |
| PRKDC | H2AX | – | phosphorylation up-regulates | 23620287 | SIGNOR-192443 | |
| PRKDC | HSP90AA1 | Thr7 | tQDQPMEE | phosphorylation unknown | 2507541 | SIGNOR-248888 |
| PRKDC | PNKP | Ser126 | PPGTPLVsQDEKRDA | phosphorylation up-regulates | 21824916 | SIGNOR-176020 |
| PRKDC | RPA2 | Thr21 | YGGAGGYtQSPGGFG | phosphorylation unknown | 9139719 | SIGNOR-248972 |
| PRKDC | PRKDC | Thr2647 | QQHDFTLtQTADGRS | phosphorylation up-regulates activity | 12186630 | SIGNOR-249160 |
| PRKDC | CASP2 | Ser139 | LSCDYDLsLPFPVCE | phosphorylation up-regulates | 19203584 | SIGNOR-183895 |
| PRKDC | LIG4 | Ser668 | DVEFCVMsGTDSQPK | phosphorylation down-regulates | 15194694 | SIGNOR-125869 |
| PRKDC | ABL1 | – | phosphorylation up-regulates activity | 9109492 | SIGNOR-279268 | |
| PRKDC | PDX1 | Thr11 | EEQYYAAtQLYKDPC | phosphorylation down-regulates quantity by destabilization | 16166097 | SIGNOR-225542 |
| PRKDC | IKBKG | Ser43 | PAMLHLPsEQGAPET | phosphorylation down-regulates activity | 31932854 | SIGNOR-277508 |
| PRKDC | DCLRE1C | Ser645 | NLSTNADsQSSSDFE | phosphorylation up-regulates | 16600297 | SIGNOR-145841 |
| PRKDC | LIG4 | Ser672 | CVMSGTDsQPKPDLE | phosphorylation down-regulates | 15194694 | SIGNOR-125873 |
| PRKDC | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 18439899 | SIGNOR-252447 |
| PRKDC | LIG4 | Thr650 | HLKAPNLtNVNKISN | phosphorylation down-regulates | 15194694 | SIGNOR-125877 |
| PRKDC | USF1 | – | phosphorylation up-regulates | 19303849 | SIGNOR-184849 | |
| PRKDC | JUN | Ser249 | LSPIDMEsQERIKAE | phosphorylation unknown | 8464713 | SIGNOR-248934 |
| PRKDC | PRKDC | Ser3205 | TPLPEDNsMNVDQDG | phosphorylation up-regulates activity | 12186630 | SIGNOR-249157 |
| PRKDC | PRKDC | Thr2620 | QGTLQTRtQEGSLSA | phosphorylation up-regulates activity | 12186630 | SIGNOR-249158 |
| PRKDC | RPA2 | Thr21 | YGGAGGYtQSPGGFG | phosphorylation up-regulates | 14872059 | SIGNOR-121869 |
| PRKDC | MCC | Ser120 | LRSELSQsQHEVNED | phosphorylation up-regulates activity | 21779472 | SIGNOR-273531 |
| PRKDC | PRKDC | Thr2609 | LTPMFVEtQASQGTL | phosphorylation up-regulates | 17189255 | SIGNOR-151449 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | phosphorylation up-regulates → | POLL PThr204 | phosphorylation up-regulates → | POLL | 28109743 | SIGNOR-273835 |
| PRKDC | phosphorylation up-regulates → | POU2F1 PThr226 | phosphorylation down-regulates ⊣ | POU2F1 | 9368058 | SIGNOR-53262 |
| PRKDC | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 15668230 | SIGNOR-133384 |
| PRKDC | phosphorylation up-regulates → | SRF PSer435 | phosphorylation up-regulates → | SRF | 8407951 | SIGNOR-248921 |
| PRKDC | phosphorylation up-regulates → | IRF3 PThr135 | phosphorylation up-regulates → | IRF3 | 11867762 | SIGNOR-115331 |
| PRKDC | phosphorylation up-regulates → | WRN PSer467 | phosphorylation up-regulates → | WRN | 24429382 | SIGNOR-203741 |
| PRKDC | phosphorylation up-regulates → | GOLPH3 PThr148 | phosphorylation up-regulates → | GOLPH3 | 24485452 | SIGNOR-253558 |
| PRKDC | phosphorylation up-regulates → | FH PThr236 | phosphorylation up-regulates → | FH | 26237645 | SIGNOR-266349 |
| PRKDC | phosphorylation up-regulates → | RPA2 PSer33 | phosphorylation down-regulates ⊣ | RPA2 | 9139719 | SIGNOR-248971 |
| PRKDC | phosphorylation up-regulates → | PPARGC1A PSer636 | phosphorylation down-regulates ⊣ | PPARGC1A | 36696363 | SIGNOR-277911 |
| PRKDC | phosphorylation up-regulates → | PRKDC PSer2624 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249156 |
| PRKDC | phosphorylation up-regulates → | PNKP PSer114 | phosphorylation up-regulates → | PNKP | 21824916 | SIGNOR-176016 |
| PRKDC | phosphorylation up-regulates → | XRCC6 PSer27 | phosphorylation up-regulates → | XRCC6 | 26337656 | SIGNOR-274022 |
| PRKDC | phosphorylation up-regulates → | WRN PSer440 | phosphorylation up-regulates → | WRN | 24429382 | SIGNOR-203737 |
| PRKDC | phosphorylation up-regulates → | PRKDC PSer2056 | phosphorylation up-regulates → | PRKDC | 17189255 | SIGNOR-151445 |
| PRKDC | phosphorylation up-regulates → | PNPT1 PSer776 | phosphorylation up-regulates → | PNPT1 | 22815474 | SIGNOR-263182 |
| PRKDC | phosphorylation up-regulates → | HNRNPU PSer59 | phosphorylation up-regulates → | HNRNPU | 19351595 | SIGNOR-185058 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2609 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249154 |
| PRKDC | phosphorylation up-regulates → | HSP90AA1 PThr5 | phosphorylation down-regulates ⊣ | HSP90AA1 | 2507541 | SIGNOR-248887 |
| PRKDC | phosphorylation up-regulates → | RPA2 PSer13 | phosphorylation down-regulates ⊣ | RPA2 | 9295339 | SIGNOR-248982 |
| PRKDC | phosphorylation up-regulates → | XRCC4 PSer328 | phosphorylation up-regulates → | XRCC4 | 26774286 | SIGNOR-277199 |
| PRKDC | phosphorylation up-regulates → | XRCC6 PSer33 | phosphorylation up-regulates → | XRCC6 | 26337656 | SIGNOR-274023 |
| PRKDC | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 18439899 | SIGNOR-252431 |
| PRKDC | phosphorylation up-regulates → | RPA2 PSer12 | phosphorylation down-regulates ⊣ | RPA2 | 9295339 | SIGNOR-248981 |
| PRKDC | phosphorylation up-regulates → | GOLPH3 PThr143 | phosphorylation up-regulates → | GOLPH3 | 24485452 | SIGNOR-253557 |
| PRKDC | phosphorylation up-regulates → | POU2F1 PSer232 | phosphorylation down-regulates ⊣ | POU2F1 | 9368058 | SIGNOR-53258 |
| PRKDC | phosphorylation up-regulates → | RPA2 PSer11 | phosphorylation down-regulates ⊣ | RPA2 | 9295339 | SIGNOR-248980 |
| PRKDC | phosphorylation up-regulates → | H1-2 PThr146 | phosphorylation down-regulates ⊣ | H1-2 | 22249259 | SIGNOR-273834 |
| PRKDC | phosphorylation up-regulates → | PRKAG1 PSer192 | phosphorylation up-regulates → | PRKAG1 | 31983282 | SIGNOR-277503 |
| PRKDC | phosphorylation up-regulates → | NHEJ1 PSer245 | phosphorylation down-regulates ⊣ | NHEJ1 | 18644470 | SIGNOR-179532 |
| PRKDC | phosphorylation up-regulates → | YBX1 PThr89 | phosphorylation up-regulates → | YBX1 | 36475703 | SIGNOR-277611 |
| PRKDC | phosphorylation up-regulates → | DCLRE1C PSer516 | phosphorylation up-regulates → | DCLRE1C | 16600297 | SIGNOR-145837 |
| PRKDC | phosphorylation up-regulates → | MCC PSer118 | phosphorylation up-regulates → | MCC | 21779472 | SIGNOR-273530 |
| PRKDC | phosphorylation up-regulates → | TOP1 PSer10 | phosphorylation down-regulates ⊣ | TOP1 | 28415827 | SIGNOR-277352 |
| PRKDC | phosphorylation up-regulates → | PRKDC PSer2612 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249155 |
| PRKDC | phosphorylation up-regulates → | RPA2 PThr21 | phosphorylation down-regulates ⊣ | RPA2 | 14872059 | SIGNOR-121873 |
| PRKDC | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 20219974 | SIGNOR-279561 |
| PRKDC | phosphorylation up-regulates → | NR3C1 PSer508 | phosphorylation down-regulates ⊣ | NR3C1 | 9038175 | SIGNOR-248965 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2638 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249159 |
| PRKDC | phosphorylation up-regulates → | PRKAG1 PThr284 | phosphorylation up-regulates → | PRKAG1 | 31983282 | SIGNOR-277504 |
| PRKDC | phosphorylation up-regulates → | MITF PSer431 | phosphorylation up-regulates → | MITF | 38316520 | SIGNOR-277899 |
| PRKDC | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 9363941 | SIGNOR-53030 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr3950 | phosphorylation down-regulates ⊣ | PRKDC | 17189255 | SIGNOR-151453 |
| PRKDC | phosphorylation up-regulates → | XRCC4 PSer327 | phosphorylation up-regulates → | XRCC4 | 26774286 | SIGNOR-277198 |
| PRKDC | phosphorylation up-regulates → | DCLRE1C PSer503 | phosphorylation up-regulates → | DCLRE1C | 16874298 | SIGNOR-148327 |
| PRKDC | phosphorylation up-regulates → | TDP1 PSer81 | phosphorylation up-regulates → | TDP1 | 19851285 | SIGNOR-188776 |
| PRKDC | phosphorylation up-regulates → | SRF PSer446 | phosphorylation up-regulates → | SRF | 8407951 | SIGNOR-248922 |
| PRKDC | phosphorylation up-regulates → | ATM PSer1987 | phosphorylation down-regulates ⊣ | ATM | 32832608 | SIGNOR-278324 |
| PRKDC | phosphorylation up-regulates → | HSP90AA1 PThr7 | phosphorylation down-regulates ⊣ | HSP90AA1 | 2507541 | SIGNOR-248888 |
| PRKDC | phosphorylation up-regulates → | PNKP PSer126 | phosphorylation up-regulates → | PNKP | 21824916 | SIGNOR-176020 |
| PRKDC | phosphorylation up-regulates → | RPA2 PThr21 | phosphorylation down-regulates ⊣ | RPA2 | 9139719 | SIGNOR-248972 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2647 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249160 |
| PRKDC | phosphorylation up-regulates → | CASP2 PSer139 | phosphorylation up-regulates → | CASP2 | 19203584 | SIGNOR-183895 |
| PRKDC | phosphorylation up-regulates → | LIG4 PSer668 | phosphorylation down-regulates ⊣ | LIG4 | 15194694 | SIGNOR-125869 |
| PRKDC | phosphorylation up-regulates → | PDX1 PThr11 | phosphorylation down-regulates ⊣ | PDX1 | 16166097 | SIGNOR-225542 |
| PRKDC | phosphorylation up-regulates → | IKBKG PSer43 | phosphorylation down-regulates ⊣ | IKBKG | 31932854 | SIGNOR-277508 |
| PRKDC | phosphorylation up-regulates → | DCLRE1C PSer645 | phosphorylation up-regulates → | DCLRE1C | 16600297 | SIGNOR-145841 |
| PRKDC | phosphorylation up-regulates → | LIG4 PSer672 | phosphorylation down-regulates ⊣ | LIG4 | 15194694 | SIGNOR-125873 |
| PRKDC | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 18439899 | SIGNOR-252447 |
| PRKDC | phosphorylation up-regulates → | LIG4 PThr650 | phosphorylation down-regulates ⊣ | LIG4 | 15194694 | SIGNOR-125877 |
| PRKDC | phosphorylation up-regulates → | JUN PSer249 | phosphorylation down-regulates ⊣ | JUN | 8464713 | SIGNOR-248934 |
| PRKDC | phosphorylation up-regulates → | PRKDC PSer3205 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249157 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2620 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249158 |
| PRKDC | phosphorylation up-regulates → | RPA2 PThr21 | phosphorylation up-regulates → | RPA2 | 14872059 | SIGNOR-121869 |
| PRKDC | phosphorylation up-regulates → | MCC PSer120 | phosphorylation up-regulates → | MCC | 21779472 | SIGNOR-273531 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2609 | phosphorylation up-regulates → | PRKDC | 17189255 | SIGNOR-151449 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKDC | phosphorylation → up-regulates activity | POLL | SIGNOR-273835 |
| PRKDC | phosphorylation down-regulates | POU2F1 | SIGNOR-53262 |
| PRKDC | phosphorylation → up-regulates activity | PLK1 | SIGNOR-279562 |
| PRKDC | phosphorylation → up-regulates activity | KAT2B | SIGNOR-280092 |
| PRKDC | phosphorylation → down-regulates activity | PARP1 | SIGNOR-280093 |
| PRKDC | phosphorylation → up-regulates | CHEK2 | SIGNOR-133384 |
| PRKDC | phosphorylation → up-regulates activity | SRF | SIGNOR-248921 |
| PRKDC | phosphorylation → up-regulates | IRF3 | SIGNOR-115331 |
| PRKDC | phosphorylation → up-regulates | WRN | SIGNOR-203741 |
| PRKDC | phosphorylation → up-regulates activity | GOLPH3 | SIGNOR-253558 |
| PRKDC | phosphorylation → up-regulates activity | FH | SIGNOR-266349 |
| PRKDC | phosphorylation → unknown | RPA2 | SIGNOR-248971 |
| PRKDC | phosphorylation down-regulates quantity by destabilization | PPARGC1A | SIGNOR-277911 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249156 |
| PRKDC | phosphorylation → up-regulates | PNKP | SIGNOR-176016 |
| PRKDC | phosphorylation → up-regulates activity | XRCC6 | SIGNOR-274022 |
| PRKDC | phosphorylation → up-regulates | WRN | SIGNOR-203737 |
| PRKDC | phosphorylation → up-regulates | PRKDC | SIGNOR-151445 |
| PRKDC | phosphorylation → up-regulates activity | PNPT1 | SIGNOR-263182 |
| PRKDC | phosphorylation → up-regulates | HNRNPU | SIGNOR-185058 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249154 |
| PRKDC | phosphorylation → unknown | HSP90AA1 | SIGNOR-248887 |
| PRKDC | phosphorylation → down-regulates activity | RPA2 | SIGNOR-248982 |
| PRKDC | phosphorylation → up-regulates activity | XRCC4 | SIGNOR-277199 |
| PRKDC | phosphorylation → up-regulates activity | XRCC6 | SIGNOR-274023 |
| PRKDC | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252431 |
| PRKDC | phosphorylation → down-regulates activity | RPA2 | SIGNOR-248981 |
| PRKDC | phosphorylation → up-regulates activity | GOLPH3 | SIGNOR-253557 |
| PRKDC | phosphorylation down-regulates | POU2F1 | SIGNOR-53258 |
| PRKDC | phosphorylation → down-regulates activity | RPA2 | SIGNOR-248980 |
| PRKDC | phosphorylation → down-regulates activity | H1-2 | SIGNOR-273834 |
| PRKDC | phosphorylation → up-regulates activity | PRKAG1 | SIGNOR-277503 |
| PRKDC | phosphorylation → unknown | NHEJ1 | SIGNOR-179532 |
| PRKDC | phosphorylation → up-regulates activity | YBX1 | SIGNOR-277611 |
| PRKDC | phosphorylation → up-regulates | DCLRE1C | SIGNOR-145837 |
| PRKDC | phosphorylation → up-regulates activity | MCC | SIGNOR-273530 |
| PRKDC | phosphorylation down-regulates quantity by destabilization | TOP1 | SIGNOR-277352 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249155 |
| PRKDC | phosphorylation → unknown | RPA2 | SIGNOR-121873 |
| PRKDC | phosphorylation → up-regulates quantity by stabilization | ESR1 | SIGNOR-279561 |
| PRKDC | phosphorylation → unknown | NR3C1 | SIGNOR-248965 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249159 |
| PRKDC | phosphorylation → up-regulates activity | PRKAG1 | SIGNOR-277504 |
| PRKDC | phosphorylation → up-regulates activity | MITF | SIGNOR-277899 |
| PRKDC | phosphorylation → up-regulates | TP53 | SIGNOR-53030 |
| PRKDC | phosphorylation down-regulates | PRKDC | SIGNOR-151453 |
| PRKDC | phosphorylation → up-regulates activity | XRCC4 | SIGNOR-277198 |
| PRKDC | phosphorylation → up-regulates | DCLRE1C | SIGNOR-148327 |
| PRKDC | phosphorylation → up-regulates | TDP1 | SIGNOR-188776 |
| PRKDC | phosphorylation → up-regulates activity | SRF | SIGNOR-248922 |
| PRKDC | phosphorylation → down-regulates activity | ATM | SIGNOR-278324 |
| PRKDC | phosphorylation → up-regulates | H2AX | SIGNOR-192443 |
| PRKDC | phosphorylation → unknown | HSP90AA1 | SIGNOR-248888 |
| PRKDC | phosphorylation → up-regulates | PNKP | SIGNOR-176020 |
| PRKDC | phosphorylation → unknown | RPA2 | SIGNOR-248972 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249160 |
| PRKDC | phosphorylation → up-regulates | CASP2 | SIGNOR-183895 |
| PRKDC | phosphorylation down-regulates | LIG4 | SIGNOR-125869 |
| PRKDC | phosphorylation → up-regulates activity | ABL1 | SIGNOR-279268 |
| PRKDC | phosphorylation down-regulates quantity by destabilization | PDX1 | SIGNOR-225542 |
| PRKDC | phosphorylation → down-regulates activity | IKBKG | SIGNOR-277508 |
| PRKDC | phosphorylation → up-regulates | DCLRE1C | SIGNOR-145841 |
| PRKDC | phosphorylation down-regulates | LIG4 | SIGNOR-125873 |
| PRKDC | phosphorylation → up-regulates activity | AKT | SIGNOR-252447 |
| PRKDC | phosphorylation down-regulates | LIG4 | SIGNOR-125877 |
| PRKDC | phosphorylation → up-regulates | USF1 | SIGNOR-184849 |
| PRKDC | phosphorylation → unknown | JUN | SIGNOR-248934 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249157 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249158 |
| PRKDC | phosphorylation → up-regulates | RPA2 | SIGNOR-121869 |
| PRKDC | phosphorylation → up-regulates activity | MCC | SIGNOR-273531 |
| PRKDC | phosphorylation → up-regulates | PRKDC | SIGNOR-151449 |