Summary

Name PRKDC
Full Name DNA-dependent protein kinase catalytic subunit
Synonyms DNA-PK catalytic subunit, DNA-PKcs, DNPK1, p460 | HYRC, HYRC1
Primary ID P78527
Links - -
Type protein
Relations 60
Pathways Cell cycle: G2/M phase transition
Inhibitors PI-103; PP121; PIK-75 Hydrochloride; 8-(4-dibenzothiophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one
Function Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation RPA2 0.14
Publications: 5 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PNKP 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CASP2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation PRKDC 0.42
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates img/direct_inhibition.png phosphorylation POU2F1 0.28
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NHEJ1 0.22
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation JUN 0.34
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PRKDC 0.42
Publications: 7 Organism: Homo Sapiens, In Vitro
Pathways:Cell cycle: G2/M phase transition
+ img/unknown.png phosphorylation RPA2 0.2
Publications: 3 Organism: In Vitro, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SRF 0.28
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation WRN 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DCLRE1C 0.62
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NR3C1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation HNRNPU 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LIG4 0.22
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TDP1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PDX1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation IRF3 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GOLPH3 0.14
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation RPA2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKDC 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation PRKDC 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates img/direct_inhibition.png phosphorylation PRKDC 0.35
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ img/unknown.png phosphorylation HSP90AA1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHEK2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PRKDC 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PRKDC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation USF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PRKDC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PRKDC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PRKDC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H2AFX 0.31
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Ku70/Ku80/DNA-PK 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization PRKDC 0.62
Publications: 1 Organism: Homo Sapiens