| Name | PRKDC |
| ID | P78527 |
| Role | substrate |
| Enzymatic Domains |
FAT 2906-3539 PROSITE-ProRule
PI3K/PI4K catalytic 3722-4053 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | PRKDC | Thr2638 | VAGQIRAtQQQHDFT | phosphorylation up-regulates activity | 12186630 | SIGNOR-249159 |
| ATM | PRKDC | Thr2609 | LTPMFVEtQASQGTL | phosphorylation up-regulates | 17189255 | SIGNOR-151441 |
| PRKDC | PRKDC | Thr2609 | LTPMFVEtQASQGTL | phosphorylation up-regulates activity | 12186630 | SIGNOR-249154 |
| PRKDC | PRKDC | Thr2609 | LTPMFVEtQASQGTL | phosphorylation up-regulates | 17189255 | SIGNOR-151449 |
| PRKDC | PRKDC | Thr3950 | GHAFGSAtQFLPVPE | phosphorylation down-regulates | 17189255 | SIGNOR-151453 |
| RET | PRKDC | Ser2056 | VQSYSYSsQDPRPAT | phosphorylation up-regulates activity | 26065416 | SIGNOR-279275 |
| PRKDC | PRKDC | Thr2620 | QGTLQTRtQEGSLSA | phosphorylation up-regulates activity | 12186630 | SIGNOR-249158 |
| PRKDC | PRKDC | Ser2056 | VQSYSYSsQDPRPAT | phosphorylation up-regulates | 17189255 | SIGNOR-151445 |
| LYN | PRKDC | – | phosphorylation down-regulates activity | 9748231 | SIGNOR-279061 | |
| PPP6C | PRKDC | – | dephosphorylation up-regulates activity | 19198648 | SIGNOR-277164 | |
| PRKDC | PRKDC | Ser2612 | MFVETQAsQGTLQTR | phosphorylation up-regulates activity | 12186630 | SIGNOR-249155 |
| CTDSP1 | PRKDC | – | dephosphorylation up-regulates activity | 32764831 | SIGNOR-277101 | |
| PRKDC | PRKDC | Thr2647 | QQHDFTLtQTADGRS | phosphorylation up-regulates activity | 12186630 | SIGNOR-249160 |
| ATR | PRKDC | Thr2609 | LTPMFVEtQASQGTL | phosphorylation up-regulates | 16908529 | SIGNOR-148722 |
| PLK1 | PRKDC | Ser3205 | TPLPEDNsMNVDQDG | phosphorylation up-regulates activity | 24844881 | SIGNOR-278188 |
| PRKDC | PRKDC | Ser3205 | TPLPEDNsMNVDQDG | phosphorylation up-regulates activity | 12186630 | SIGNOR-249157 |
| PRKDC | PRKDC | Ser2624 | QTRTQEGsLSARWPV | phosphorylation up-regulates activity | 12186630 | SIGNOR-249156 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2638 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249159 |
| ATM | phosphorylation up-regulates → | PRKDC PThr2609 | phosphorylation up-regulates → | PRKDC | 17189255 | SIGNOR-151441 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2609 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249154 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2609 | phosphorylation up-regulates → | PRKDC | 17189255 | SIGNOR-151449 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr3950 | phosphorylation down-regulates ⊣ | PRKDC | 17189255 | SIGNOR-151453 |
| RET | phosphorylation up-regulates → | PRKDC PSer2056 | phosphorylation up-regulates → | PRKDC | 26065416 | SIGNOR-279275 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2620 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249158 |
| PRKDC | phosphorylation up-regulates → | PRKDC PSer2056 | phosphorylation up-regulates → | PRKDC | 17189255 | SIGNOR-151445 |
| PRKDC | phosphorylation up-regulates → | PRKDC PSer2612 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249155 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2647 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249160 |
| ATR | phosphorylation up-regulates → | PRKDC PThr2609 | phosphorylation up-regulates → | PRKDC | 16908529 | SIGNOR-148722 |
| PLK1 | phosphorylation up-regulates → | PRKDC PSer3205 | phosphorylation up-regulates → | PRKDC | 24844881 | SIGNOR-278188 |
| PRKDC | phosphorylation up-regulates → | PRKDC PSer3205 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249157 |
| PRKDC | phosphorylation up-regulates → | PRKDC PSer2624 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249156 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249159 |
| ATM | phosphorylation → up-regulates | PRKDC | SIGNOR-151441 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249154 |
| PRKDC | phosphorylation → up-regulates | PRKDC | SIGNOR-151449 |
| PRKDC | phosphorylation down-regulates | PRKDC | SIGNOR-151453 |
| RET | phosphorylation → up-regulates activity | PRKDC | SIGNOR-279275 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249158 |
| PRKDC | phosphorylation → up-regulates | PRKDC | SIGNOR-151445 |
| LYN | phosphorylation → down-regulates activity | PRKDC | SIGNOR-279061 |
| PPP6C | dephosphorylation → up-regulates activity | PRKDC | SIGNOR-277164 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249155 |
| CTDSP1 | dephosphorylation → up-regulates activity | PRKDC | SIGNOR-277101 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249160 |
| ATR | phosphorylation → up-regulates | PRKDC | SIGNOR-148722 |
| PLK1 | phosphorylation → up-regulates activity | PRKDC | SIGNOR-278188 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249157 |
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249156 |