| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | PRKDC | Thr2609 | LTPMFVEtQASQGTL | phosphorylation up-regulates activity | 12186630 | SIGNOR-249154 |
| PRKDC | PRKDC | Thr2609 | LTPMFVEtQASQGTL | phosphorylation up-regulates | 17189255 | SIGNOR-151449 |
| ATR | PRKDC | Thr2609 | LTPMFVEtQASQGTL | phosphorylation up-regulates | 16908529 | SIGNOR-148722 |
| ATM | PRKDC | Thr2609 | LTPMFVEtQASQGTL | phosphorylation up-regulates | 17189255 | SIGNOR-151441 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2609 | phosphorylation up-regulates → | PRKDC | 12186630 | SIGNOR-249154 |
| PRKDC | phosphorylation up-regulates → | PRKDC PThr2609 | phosphorylation up-regulates → | PRKDC | 17189255 | SIGNOR-151449 |
| ATR | phosphorylation up-regulates → | PRKDC PThr2609 | phosphorylation up-regulates → | PRKDC | 16908529 | SIGNOR-148722 |
| ATM | phosphorylation up-regulates → | PRKDC PThr2609 | phosphorylation up-regulates → | PRKDC | 17189255 | SIGNOR-151441 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKDC | phosphorylation → up-regulates activity | PRKDC | SIGNOR-249154 |
| PRKDC | phosphorylation → up-regulates | PRKDC | SIGNOR-151449 |
| ATR | phosphorylation → up-regulates | PRKDC | SIGNOR-148722 |
| ATM | phosphorylation → up-regulates | PRKDC | SIGNOR-151441 |
