| Name | ADAM17 |
| ID | P78536 |
| Role | substrate |
| Enzymatic Domains |
Peptidase M12B 223-474 PROSITE-ProRule
Disintegrin 475-563 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | ADAM17 | – | phosphorylation up-regulates activity | 25371038 | SIGNOR-279115 | |
| ERK1/2 | ADAM17 | Thr735 | KPFPAPQtPGRLQPA | phosphorylation up-regulates | 12058067 | SIGNOR-89614 |
| MAPK3 | ADAM17 | Thr735 | KPFPAPQtPGRLQPA | phosphorylation up-regulates | 12058067 | SIGNOR-89625 |
| MAPK14 | ADAM17 | Thr735 | KPFPAPQtPGRLQPA | phosphorylation up-regulates activity | 20188673 | SIGNOR-163970 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | ADAM17 PThr735 | phosphorylation up-regulates → | ADAM17 | 12058067 | SIGNOR-89614 |
| MAPK3 | phosphorylation up-regulates → | ADAM17 PThr735 | phosphorylation up-regulates → | ADAM17 | 12058067 | SIGNOR-89625 |
| MAPK14 | phosphorylation up-regulates → | ADAM17 PThr735 | phosphorylation up-regulates → | ADAM17 | 20188673 | SIGNOR-163970 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates activity | ADAM17 | SIGNOR-279115 |
| ERK1/2 | phosphorylation → up-regulates | ADAM17 | SIGNOR-89614 |
| MAPK3 | phosphorylation → up-regulates | ADAM17 | SIGNOR-89625 |
| MAPK14 | phosphorylation → up-regulates activity | ADAM17 | SIGNOR-163970 |