Summary

Name ADAM17
Full Name Disintegrin and metalloproteinase domain-containing protein 17
Synonyms ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme | CSVP, TACE
Primary ID P78536
Links - -
Type protein
Relations 14
Pathways NOTCH Signaling, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
Function Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation ADAM17 0.34
Publications: 1 Organism: Cricetulus Griseus
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation ADAM17 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ADAM17 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage HBEGF
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png EGFR 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage NOTCH 0.23
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png cleavage MUC1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage TGFA
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage NOTCH1 0.36
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates img/direct-activation.png cleavage NOTCH 0.23
Publications: 2 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png cleavage TNF 0.47
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png cleavage AREG
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage EREG
Publications: 1 Organism: Homo Sapiens