| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | ADAM17 | Thr735 | KPFPAPQtPGRLQPA | phosphorylation up-regulates | 12058067 | SIGNOR-89625 |
| MAPK14 | ADAM17 | Thr735 | KPFPAPQtPGRLQPA | phosphorylation up-regulates activity | 20188673 | SIGNOR-163970 |
| ERK1/2 | ADAM17 | Thr735 | KPFPAPQtPGRLQPA | phosphorylation up-regulates | 12058067 | SIGNOR-89614 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | ADAM17 PThr735 | phosphorylation up-regulates → | ADAM17 | 12058067 | SIGNOR-89625 |
| MAPK14 | phosphorylation up-regulates → | ADAM17 PThr735 | phosphorylation up-regulates → | ADAM17 | 20188673 | SIGNOR-163970 |
| ERK1/2 | phosphorylation up-regulates → | ADAM17 PThr735 | phosphorylation up-regulates → | ADAM17 | 12058067 | SIGNOR-89614 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates | ADAM17 | SIGNOR-89625 |
| MAPK14 | phosphorylation → up-regulates activity | ADAM17 | SIGNOR-163970 |
| ERK1/2 | phosphorylation → up-regulates | ADAM17 | SIGNOR-89614 |