| Name | SMAD3 |
| ID | P84022 |
| Role | substrate |
| Enzymatic Domains |
MH1 10-136 PROSITE-ProRule
MH2 232-425 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | phosphorylation up-regulates activity | 15520018 | SIGNOR-250113 |
| PPP2CA | SMAD3 | – | dephosphorylation down-regulates | 19951945 | SIGNOR-161919 | |
| CSNK1G2 | SMAD3 | Ser418 | LTQMGSPsIRCSSVS | phosphorylation down-regulates | 18794808 | SIGNOR-181069 |
| CTDSP2 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248295 |
| MAPK1 | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | phosphorylation unknown | 15241418 | SIGNOR-126744 |
| MAPK1 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914161 | SIGNOR-161617 |
| CTDSPL | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248306 |
| CDK8 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 19914161 | SIGNOR-161561 |
| MAPK1 | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | phosphorylation down-regulates activity | 19914161 | SIGNOR-161609 |
| TGFBR1 | SMAD3 | Ser425 | SIRCSSVs | phosphorylation up-regulates activity | 19458083 | SIGNOR-235380 |
| CDK4 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation unknown | 15241418 | SIGNOR-250767 |
| MAPK1 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914168 | SIGNOR-161706 |
| CDK2 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates activity | 15241418 | SIGNOR-217734 |
| TGFBR1 | SMAD3 | – | phosphorylation up-regulates activity | 19701891 | SIGNOR-254361 | |
| CTDSP2 | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248293 |
| CDK2 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 19114991 | SIGNOR-182971 |
| CDK2 | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | phosphorylation unknown | 15241418 | SIGNOR-250749 |
| CDK8 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914161 | SIGNOR-161557 |
| PPP2CA | SMAD3 | – | dephosphorylation down-regulates | 20704570 | SIGNOR-167480 | |
| MAPK1 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 10197981 | SIGNOR-66746 |
| MAPK1 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 10197981 | SIGNOR-66742 |
| CDK2 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates activity | 15241418 | SIGNOR-232134 |
| Gbeta | SMAD3 | – | phosphorylation down-regulates | 10197981 | SIGNOR-270015 | |
| CDK9 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914168 | SIGNOR-161678 |
| CTDSP2 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248294 |
| MAPK1 | SMAD3 | – | phosphorylation down-regulates | 10197981 | SIGNOR-66749 | |
| CDK4 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19114991 | SIGNOR-182979 |
| CKM complex | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates quantity by destabilization | 19914168 | SIGNOR-273146 |
| CDK8 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914168 | SIGNOR-161646 |
| TGFBR1 | SMAD3 | Ser423 | SPSIRCSsVS | phosphorylation up-regulates activity | 19458083 | SIGNOR-235385 |
| CDK2 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 15241418 | SIGNOR-126736 |
| CDK2 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates | 15241418 | SIGNOR-126740 |
| MAPK3 | SMAD3 | – | phosphorylation down-regulates | 10197981 | SIGNOR-66781 | |
| CDK4 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 15241418 | SIGNOR-232146 |
| CDK4 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates activity | 15241418 | SIGNOR-232138 |
| PPM1A | SMAD3 | – | dephosphorylation down-regulates activity | 16751101 | SIGNOR-232110 | |
| MAPK14 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation up-regulates activity | 15520018 | SIGNOR-250112 |
| MAPK14 | SMAD3 | – | phosphorylation up-regulates activity | 14512875 | SIGNOR-236136 | |
| CDK9 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 19914161 | SIGNOR-161589 |
| MTMR4 | SMAD3 | – | dephosphorylation down-regulates | 20061380 | SIGNOR-163034 | |
| CTDSPL | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248307 |
| CDK8 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation down-regulates activity | 19914161 | SIGNOR-161553 |
| CKM complex | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273142 |
| CTDSP1 | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248791 |
| MAPK1 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation unknown | 15241418 | SIGNOR-126748 |
| CTDSP1 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248793 |
| CTDSPL | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248308 |
| MAPK1 | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | phosphorylation unknown | 19914168 | SIGNOR-161698 |
| CDK2 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates | 19114991 | SIGNOR-182975 |
| CDK2 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19114991 | SIGNOR-182967 |
| CTDSP1 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248792 |
| CDK4 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates activity | 15241418 | SIGNOR-232142 |
| CDK4 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates | 19114991 | SIGNOR-182983 |
| CDK2 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 15241418 | SIGNOR-126732 |
| ACVR1B | SMAD3 | – | phosphorylation up-regulates activity | 14517293 | SIGNOR-235160 | |
| CDK9 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914161 | SIGNOR-161585 |
| ERK1/2 | SMAD3 | – | phosphorylation down-regulates | 10197981 | SIGNOR-270142 | |
| CDK9 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation down-regulates activity | 19914161 | SIGNOR-161581 |
| CKM complex | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273147 |
| CDK2 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation unknown | 15241418 | SIGNOR-250750 |
| CKM complex | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation down-regulates activity | 19914161 | SIGNOR-273151 |
| GSK3B | SMAD3 | Thr66 | NVNTKCItIPRSLDG | phosphorylation down-regulates quantity by destabilization | 18172167 | SIGNOR-160318 |
| MAPK1 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation down-regulates activity | 19914161 | SIGNOR-161613 |
| ACVR2B | SMAD3 | – | phosphorylation up-regulates activity | 21966641 | SIGNOR-254985 | |
| PPM1A | SMAD3 | – | dephosphorylation down-regulates | 16751101 | SIGNOR-146922 | |
| CDK4 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 19114991 | SIGNOR-182822 |
| SRC | SMAD3 | – | phosphorylation up-regulates activity | 28943431 | SIGNOR-279292 | |
| CDK4 | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | phosphorylation unknown | 15241418 | SIGNOR-250766 |
| JNK | SMAD3 | – | phosphorylation up-regulates activity | 10601313 | SIGNOR-236113 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | phosphorylation up-regulates → | SMAD3 PSer204 | phosphorylation up-regulates → | SMAD3 | 15520018 | SIGNOR-250113 |
| CSNK1G2 | phosphorylation up-regulates → | SMAD3 PSer418 | phosphorylation down-regulates ⊣ | SMAD3 | 18794808 | SIGNOR-181069 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD3 PSer213 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248295 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer204 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-126744 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161617 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD3 PSer204 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248306 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161561 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer204 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161609 |
| TGFBR1 | phosphorylation up-regulates → | SMAD3 PSer425 | phosphorylation up-regulates → | SMAD3 | 19458083 | SIGNOR-235380 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-250767 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-161706 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-217734 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD3 PSer204 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248293 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182971 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PSer204 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-250749 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161557 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 10197981 | SIGNOR-66746 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 10197981 | SIGNOR-66742 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232134 |
| CDK9 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-161678 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD3 PSer208 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248294 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182979 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-273146 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-161646 |
| TGFBR1 | phosphorylation up-regulates → | SMAD3 PSer423 | phosphorylation up-regulates → | SMAD3 | 19458083 | SIGNOR-235385 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-126736 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-126740 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232146 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232138 |
| MAPK14 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation up-regulates → | SMAD3 | 15520018 | SIGNOR-250112 |
| CDK9 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161589 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD3 PSer208 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248307 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161553 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-273142 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD3 PSer204 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248791 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-126748 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD3 PSer213 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248793 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD3 PSer213 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248308 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer204 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-161698 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182975 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182967 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD3 PSer208 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248792 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232142 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182983 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-126732 |
| CDK9 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161585 |
| CDK9 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161581 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-273147 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-250750 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-273151 |
| GSK3B | phosphorylation up-regulates → | SMAD3 PThr66 | phosphorylation down-regulates ⊣ | SMAD3 | 18172167 | SIGNOR-160318 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161613 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182822 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer204 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-250766 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-250113 |
| PPP2CA | dephosphorylation down-regulates | SMAD3 | SIGNOR-161919 |
| CSNK1G2 | phosphorylation down-regulates | SMAD3 | SIGNOR-181069 |
| CTDSP2 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248295 |
| MAPK1 | phosphorylation → unknown | SMAD3 | SIGNOR-126744 |
| MAPK1 | phosphorylation down-regulates | SMAD3 | SIGNOR-161617 |
| CTDSPL | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248306 |
| CDK8 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161561 |
| MAPK1 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161609 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-235380 |
| CDK4 | phosphorylation → unknown | SMAD3 | SIGNOR-250767 |
| MAPK1 | phosphorylation down-regulates | SMAD3 | SIGNOR-161706 |
| CDK2 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-217734 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-254361 |
| CTDSP2 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248293 |
| CDK2 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-182971 |
| CDK2 | phosphorylation → unknown | SMAD3 | SIGNOR-250749 |
| CDK8 | phosphorylation down-regulates | SMAD3 | SIGNOR-161557 |
| PPP2CA | dephosphorylation down-regulates | SMAD3 | SIGNOR-167480 |
| MAPK1 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-66746 |
| MAPK1 | phosphorylation down-regulates | SMAD3 | SIGNOR-66742 |
| CDK2 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232134 |
| Gbeta | phosphorylation down-regulates | SMAD3 | SIGNOR-270015 |
| CDK9 | phosphorylation down-regulates | SMAD3 | SIGNOR-161678 |
| CTDSP2 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248294 |
| MAPK1 | phosphorylation down-regulates | SMAD3 | SIGNOR-66749 |
| CDK4 | phosphorylation down-regulates | SMAD3 | SIGNOR-182979 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD3 | SIGNOR-273146 |
| CDK8 | phosphorylation down-regulates | SMAD3 | SIGNOR-161646 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-235385 |
| CDK2 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-126736 |
| CDK2 | phosphorylation down-regulates | SMAD3 | SIGNOR-126740 |
| MAPK3 | phosphorylation down-regulates | SMAD3 | SIGNOR-66781 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232146 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232138 |
| PPM1A | dephosphorylation → down-regulates activity | SMAD3 | SIGNOR-232110 |
| MAPK14 | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-250112 |
| MAPK14 | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-236136 |
| CDK9 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161589 |
| MTMR4 | dephosphorylation down-regulates | SMAD3 | SIGNOR-163034 |
| CTDSPL | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248307 |
| CDK8 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161553 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD3 | SIGNOR-273142 |
| CTDSP1 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248791 |
| MAPK1 | phosphorylation → unknown | SMAD3 | SIGNOR-126748 |
| CTDSP1 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248793 |
| CTDSPL | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248308 |
| MAPK1 | phosphorylation → unknown | SMAD3 | SIGNOR-161698 |
| CDK2 | phosphorylation down-regulates | SMAD3 | SIGNOR-182975 |
| CDK2 | phosphorylation down-regulates | SMAD3 | SIGNOR-182967 |
| CTDSP1 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248792 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232142 |
| CDK4 | phosphorylation down-regulates | SMAD3 | SIGNOR-182983 |
| CDK2 | phosphorylation down-regulates | SMAD3 | SIGNOR-126732 |
| ACVR1B | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-235160 |
| CDK9 | phosphorylation down-regulates | SMAD3 | SIGNOR-161585 |
| ERK1/2 | phosphorylation down-regulates | SMAD3 | SIGNOR-270142 |
| CDK9 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161581 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD3 | SIGNOR-273147 |
| CDK2 | phosphorylation → unknown | SMAD3 | SIGNOR-250750 |
| CKM complex | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-273151 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | SMAD3 | SIGNOR-160318 |
| MAPK1 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161613 |
| ACVR2B | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-254985 |
| PPM1A | dephosphorylation down-regulates | SMAD3 | SIGNOR-146922 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-182822 |
| SRC | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-279292 |
| CDK4 | phosphorylation → unknown | SMAD3 | SIGNOR-250766 |
| JNK | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-236113 |