Summary

Name SMAD3
Full Name Mothers against decapentaplegic homolog 3
Synonyms MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3 | MADH3
Primary ID P84022
Links - -
Type protein
Relations 143
Pathways Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, FAP: TGF beta, Fibrosis, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Hepatocellular Tumor, Macrophage: Polarization and myogenesis, Multiple sclerosis, Macrophage: TGF beta, Myostatin, Osteoblast: TGF beta, Pancreatic ductal adenocarcinoma (PDA), SAPK/JNK Signaling, SARS-CoV FIBROSIS, Satellite: FST transcriptional regulation, Satellite: Myostatin, TGF-beta Signaling, Thyroid Hormone Metabolism, T-Lymphocyte: TGF beta, TGFb in cancer
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png acetylation SMAD3 0.68
Publications: 2 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates quantity by stabilization img/direct-activation.png acetylation SMAD3 0.726
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS
+ img/unknown.png phosphorylation SMAD3 0.736
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SMAD3 0.393
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SMAD3 0.393
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD3 0.736
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SMAD3 0.403
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD3 0.558
Publications: 3 Organism: Homo Sapiens, Rattus Norvegicus
Pathways:TGF-beta Signaling
+ img/unknown.png phosphorylation SMAD3 0.747
Publications: 2 Organism: In Vitro
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ img/unknown.png phosphorylation SMAD3 0.732
Publications: 2 Organism: In Vitro
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD3 0.419
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD3 0.544
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD3 0.605
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.732
Publications: 4 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.605
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.736
Publications: 4 Organism: Homo Sapiens
Tissue: Lung, Breast
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD3 0.747
Publications: 4 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.544
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SMAD3 0.419
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.747
Publications: 2 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD3 0.732
Publications: 4 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.342
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD3 0.806
Publications: 3 Organism: Mus Musculus, Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Fibrosis, Cell cycle: G1/S phase transition, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SMAD3 0.505
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYC 0.671
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Hepatocellular Tumor
+ down-regulates activity img/direct_inhibition.png binding SMAD3 0.74
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling, TGF-beta Signaling
+ down-regulates activity img/direct_inhibition.png binding FOXA1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.565
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD3 0.2
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Fibrosis, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SAPK/JNK Signaling, SARS-CoV FIBROSIS, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer
+ up-regulates activity img/direct-activation.png binding SMAD3 0.532
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD3 0.489
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation SMAD3 0.593
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS, TGF-beta Signaling
+ down-regulates activity img/direct_inhibition.png binding SMAD3 0.593
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS, TGF-beta Signaling
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD3 0.792
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization, binding SMAD3 0.852
Publications: 3 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SMAD3 0.532
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ down-regulates img/direct_inhibition.png ubiquitination SMAD3 0.637
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding SMAD3/PIAS3 0.577
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization SMAD3 0.497
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png FOXP3 0.545
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD3 0.532
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates img/direct-activation.png binding SMAD3 0.499
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RUNX2 0.727
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates img/direct_inhibition.png binding SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD3 0.603
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CEBPA 0.385
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2B 0.544
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer
+ down-regulates activity img/direct_inhibition.png binding CEBPB 0.576
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD3 0.603
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination SMAD3 0.431
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD3 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates activity img/direct_inhibition.png binding SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ubiquitination SMAD3 0.265
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding SMAD3 0.648
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png ubiquitination SMAD3 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD3 0.563
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, TGFb in cancer
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.719
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates img/direct-activation.png binding SMAD3 0.661
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SMAD3 0.649
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD3 0.523
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD3 0.563
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SMAD3 0.712
Publications: 2 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MYC 0.671
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Hepatocellular Tumor
+ down-regulates activity img/direct_inhibition.png binding SMAD3 0.671
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Hepatocellular Tumor
+ up-regulates activity img/direct-activation.png binding SMAD4 0.691
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer
+ down-regulates activity img/direct_inhibition.png binding PAX6 0.411
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD3 0.523
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, TGF-beta Signaling
+ down-regulates img/direct_inhibition.png relocalization SMAD3 0.399
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDC25A 0.546
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ down-regulates img/direct_inhibition.png binding SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), Thyroid Hormone Metabolism
+ down-regulates activity img/direct_inhibition.png binding PAX8 0.374
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates img/direct-activation.png binding SMAD3 0.526
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization SMAD3 0.399
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD3 0.676
Publications: 1 Organism: Mus Musculus
Pathways:Multiple sclerosis
+ down-regulates img/direct_inhibition.png binding SMAD3 0.407
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates img/direct_inhibition.png binding SMAD3 0.632
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV FIBROSIS
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD3 0.637
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding SMAD3/JUN 0.74
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD3 0.577
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deubiquitination SMAD3 0.408
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Colorectal Carcinoma
+ up-regulates img/direct-activation.png binding NOTCH 0.717
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding SMAD3 0.508
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SMAD3 0.475
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates img/direct_inhibition.png ubiquitination SMAD3 0.792
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding SMAD3 0.283
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding NKX2-1 0.297
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates img/direct-activation.png binding SMAD3 0.674
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png LEF1 0.534
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Hepatocellular Tumor
+ form complex img/form-complex.png binding SMAD3/SMAD4 0.691
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, TGF-beta Signaling, TGFb in cancer
+ up-regulates img/direct-activation.png binding SMAD3 0.577
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Fibrosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS, TGF-beta Signaling
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.607
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates activity img/direct-activation.png phosphorylation SMAD3 0.729
Publications: 1 Organism: Mus Musculus
Pathways:Multiple sclerosis