| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation unknown | 15241418 | SIGNOR-126748 |
| CDK2 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation unknown | 15241418 | SIGNOR-250750 |
| CTDSP2 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248294 |
| MAPK14 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation up-regulates activity | 15520018 | SIGNOR-250112 |
| CDK4 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation unknown | 15241418 | SIGNOR-250767 |
| CKM complex | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation down-regulates activity | 19914161 | SIGNOR-273151 |
| MAPK1 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation down-regulates activity | 19914161 | SIGNOR-161613 |
| CDK8 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation down-regulates activity | 19914161 | SIGNOR-161553 |
| CTDSPL | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248307 |
| CDK9 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation down-regulates activity | 19914161 | SIGNOR-161581 |
| CTDSP1 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248792 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-126748 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-250750 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD3 PSer208 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248294 |
| MAPK14 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation up-regulates → | SMAD3 | 15520018 | SIGNOR-250112 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-250767 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-273151 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161613 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161553 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD3 PSer208 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248307 |
| CDK9 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161581 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD3 PSer208 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248792 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → unknown | SMAD3 | SIGNOR-126748 |
| CDK2 | phosphorylation → unknown | SMAD3 | SIGNOR-250750 |
| CTDSP2 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248294 |
| MAPK14 | phosphorylation → up-regulates activity | SMAD3 | SIGNOR-250112 |
| CDK4 | phosphorylation → unknown | SMAD3 | SIGNOR-250767 |
| CKM complex | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-273151 |
| MAPK1 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161613 |
| CDK8 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161553 |
| CTDSPL | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248307 |
| CDK9 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161581 |
| CTDSP1 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248792 |
