| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19114991 | SIGNOR-182967 |
| CDK2 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates activity | 15241418 | SIGNOR-232134 |
| CTDSPL | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248308 |
| CDK9 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914168 | SIGNOR-161678 |
| CDK4 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates activity | 15241418 | SIGNOR-232142 |
| CKM complex | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273147 |
| CDK4 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19114991 | SIGNOR-182979 |
| MAPK1 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914161 | SIGNOR-161617 |
| CDK8 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914161 | SIGNOR-161557 |
| CDK8 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914168 | SIGNOR-161646 |
| MAPK1 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 10197981 | SIGNOR-66742 |
| CDK2 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 15241418 | SIGNOR-126732 |
| MAPK1 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914168 | SIGNOR-161706 |
| CTDSP1 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248793 |
| CTDSP2 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248295 |
| CKM complex | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates quantity by destabilization | 19914168 | SIGNOR-273146 |
| CDK9 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19914161 | SIGNOR-161585 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182967 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232134 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD3 PSer213 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248308 |
| CDK9 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-161678 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232142 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-273147 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182979 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161617 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161557 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-161646 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 10197981 | SIGNOR-66742 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-126732 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-161706 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD3 PSer213 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248793 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD3 PSer213 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248295 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914168 | SIGNOR-273146 |
| CDK9 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161585 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation down-regulates | SMAD3 | SIGNOR-182967 |
| CDK2 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232134 |
| CTDSPL | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248308 |
| CDK9 | phosphorylation down-regulates | SMAD3 | SIGNOR-161678 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232142 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD3 | SIGNOR-273147 |
| CDK4 | phosphorylation down-regulates | SMAD3 | SIGNOR-182979 |
| MAPK1 | phosphorylation down-regulates | SMAD3 | SIGNOR-161617 |
| CDK8 | phosphorylation down-regulates | SMAD3 | SIGNOR-161557 |
| CDK8 | phosphorylation down-regulates | SMAD3 | SIGNOR-161646 |
| MAPK1 | phosphorylation down-regulates | SMAD3 | SIGNOR-66742 |
| CDK2 | phosphorylation down-regulates | SMAD3 | SIGNOR-126732 |
| MAPK1 | phosphorylation down-regulates | SMAD3 | SIGNOR-161706 |
| CTDSP1 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248793 |
| CTDSP2 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248295 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD3 | SIGNOR-273146 |
| CDK9 | phosphorylation down-regulates | SMAD3 | SIGNOR-161585 |
