| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates | 15241418 | SIGNOR-126740 |
| CDK4 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates | 19114991 | SIGNOR-182983 |
| CDK4 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates activity | 15241418 | SIGNOR-232138 |
| CDK2 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates | 19114991 | SIGNOR-182975 |
| CDK2 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates activity | 15241418 | SIGNOR-217734 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-126740 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182983 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232138 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182975 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-217734 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation down-regulates | SMAD3 | SIGNOR-126740 |
| CDK4 | phosphorylation down-regulates | SMAD3 | SIGNOR-182983 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232138 |
| CDK2 | phosphorylation down-regulates | SMAD3 | SIGNOR-182975 |
| CDK2 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-217734 |
