| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK9 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 19914161 | SIGNOR-161589 |
| CDK8 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 19914161 | SIGNOR-161561 |
| CDK4 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 19114991 | SIGNOR-182822 |
| CDK2 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 15241418 | SIGNOR-126736 |
| CKM complex | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273142 |
| CDK4 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 15241418 | SIGNOR-232146 |
| MAPK1 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 10197981 | SIGNOR-66746 |
| CDK2 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 19114991 | SIGNOR-182971 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK9 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161589 |
| CDK8 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-161561 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182822 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-126736 |
| CKM complex | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19914161 | SIGNOR-273142 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232146 |
| MAPK1 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 10197981 | SIGNOR-66746 |
| CDK2 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182971 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK9 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161589 |
| CDK8 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-161561 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-182822 |
| CDK2 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-126736 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD3 | SIGNOR-273142 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232146 |
| MAPK1 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-66746 |
| CDK2 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-182971 |
