Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDK4	SMAD3	Thr8 View in OncoXplorer	MSSILPFtPPIVKRL	phosphorylation down-regulates activity	15241418	SIGNOR-232138
CDK2	SMAD3	Thr8 View in OncoXplorer	MSSILPFtPPIVKRL	phosphorylation down-regulates	19114991	SIGNOR-182975
CDK2	SMAD3	Thr8 View in OncoXplorer	MSSILPFtPPIVKRL	phosphorylation down-regulates activity	15241418	SIGNOR-217734
CDK2	SMAD3	Thr8 View in OncoXplorer	MSSILPFtPPIVKRL	phosphorylation down-regulates	15241418	SIGNOR-126740
CDK4	SMAD3	Thr8 View in OncoXplorer	MSSILPFtPPIVKRL	phosphorylation down-regulates	19114991	SIGNOR-182983

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDK4	phosphorylation up-regulates →	SMAD3 PThr8	phosphorylation down-regulates ⊣	SMAD3	15241418	SIGNOR-232138
CDK2	phosphorylation up-regulates →	SMAD3 PThr8	phosphorylation down-regulates ⊣	SMAD3	19114991	SIGNOR-182975
CDK2	phosphorylation up-regulates →	SMAD3 PThr8	phosphorylation down-regulates ⊣	SMAD3	15241418	SIGNOR-217734
CDK2	phosphorylation up-regulates →	SMAD3 PThr8	phosphorylation down-regulates ⊣	SMAD3	15241418	SIGNOR-126740
CDK4	phosphorylation up-regulates →	SMAD3 PThr8	phosphorylation down-regulates ⊣	SMAD3	19114991	SIGNOR-182983

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDK4	phosphorylation → down-regulates activity	SMAD3	SIGNOR-232138
CDK2	phosphorylation down-regulates	SMAD3	SIGNOR-182975
CDK2	phosphorylation → down-regulates activity	SMAD3	SIGNOR-217734
CDK2	phosphorylation down-regulates	SMAD3	SIGNOR-126740
CDK4	phosphorylation down-regulates	SMAD3	SIGNOR-182983