Entity Details

Name CDK16
ID Q00536
Role kinase
Enzymatic Domains
Protein kinase 165-446
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK16PRC1Thr481RRGLAPNtPGKARKLphosphorylation
up-regulates activity		35449080SIGNOR-273017
CDK16TP53Ser315LPNNTSSsPQPKKKPphosphorylation
down-regulates activity		29344296SIGNOR-278354
CDK16PRKAR1ASer83DSREDEIsPPPPNPVphosphorylation
up-regulates activity		25605337SIGNOR-273018
CDK16NSFSer569FPFIKICsPDKMIGFphosphorylation
down-regulates activity		16461345SIGNOR-279511
CDK16CDKN1BSer10NVRVSNGsPSLERMDphosphorylation
down-regulates quantity		25205104SIGNOR-278214
CDK16CDKN1BSer10NVRVSNGsPSLERMDphosphorylation
down-regulates quantity by destabilization		25205104SIGNOR-273016
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK16phosphorylation
up-regulates
→
PRC1
PThr481		phosphorylation
up-regulates
→		PRC135449080SIGNOR-273017
CDK16phosphorylation
up-regulates
→
TP53
PSer315		phosphorylation
down-regulates
⊣		TP5329344296SIGNOR-278354
CDK16phosphorylation
up-regulates
→
PRKAR1A
PSer83		phosphorylation
up-regulates
→		PRKAR1A25605337SIGNOR-273018
CDK16phosphorylation
up-regulates
→
NSF
PSer569		phosphorylation
down-regulates
⊣		NSF16461345SIGNOR-279511
CDK16phosphorylation
up-regulates
→
CDKN1B
PSer10		phosphorylation
down-regulates
⊣		CDKN1B25205104SIGNOR-278214
CDK16phosphorylation
up-regulates
→
CDKN1B
PSer10		phosphorylation
down-regulates
⊣		CDKN1B25205104SIGNOR-273016
Regulator Mechanism/Effect Target SIGNOR-ID
CDK16phosphorylation
→
up-regulates activity 		PRC1SIGNOR-273017
CDK16phosphorylation
→
down-regulates activity 		TP53SIGNOR-278354
CDK16phosphorylation
→
up-regulates activity 		PRKAR1ASIGNOR-273018
CDK16phosphorylation
→
down-regulates activity 		NSFSIGNOR-279511
CDK16phosphorylation
→
down-regulates quantity 		CDKN1BSIGNOR-278214
CDK16phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		CDKN1BSIGNOR-273016