| Name | MDM2 |
| ID | Q00987 |
| Role | substrate |
| Enzymatic Domains |
SWIB/MDM2 26-109 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | MDM2 | Ser429 | KEESVESsLPLNAIE | phosphorylation down-regulates activity | 19816404 | SIGNOR-188412 |
| ATR | MDM2 | Ser407 | SSSIIYSsQEDVKEF | phosphorylation down-regulates activity | 14654783 | SIGNOR-119546 |
| MAPKAPK2 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 15688025 | SIGNOR-133560 |
| DAPK3 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 15001356 | SIGNOR-123159 |
| PDXP | MDM2 | Ser166 | SSRRRAIsETEENSD | dephosphorylation down-regulates activity | 33414453 | SIGNOR-277151 |
| PPP2CB | MDM2 | Thr216 | RSSSSEStGTPSNPD | dephosphorylation up-regulates | 11983168 | SIGNOR-86736 |
| PPP2CA | MDM2 | Thr216 | RSSSSEStGTPSNPD | dephosphorylation up-regulates activity | 11983168 | SIGNOR-248636 |
| AKT | MDM2 | Ser188 | RKRHKSDsISLSFDE | phosphorylation up-regulates activity | 15169778 | SIGNOR-244300 |
| PIM | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates | 18467333 | SIGNOR-259434 |
| HIPK2 | MDM2 | – | phosphorylation down-regulates activity | 16212962 | SIGNOR-279465 | |
| CSNK1D | MDM2 | Ser246 | DSVSDQFsVEFEVES | phosphorylation down-regulates | 20708156 | SIGNOR-167509 |
| CSNK1D | MDM2 | Ser253 | SVEFEVEsLDSEDYS | phosphorylation down-regulates | 12167711 | SIGNOR-91195 |
| ATM | MDM2 | Ser395 | SQESEDYsQPSTSSS | phosphorylation down-regulates activity | 11331603 | SIGNOR-107256 |
| PIM | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates | 18467333 | SIGNOR-259433 |
| PPP2CB | MDM2 | Thr216 | RSSSSEStGTPSNPD | dephosphorylation up-regulates activity | 11983168 | SIGNOR-248593 |
| AKT1 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 11504915 | SIGNOR-116270 |
| ATM | MDM2 | Ser395 | SQESEDYsQPSTSSS | phosphorylation down-regulates activity | 12383858 | SIGNOR-94268 |
| PLK1 | MDM2 | Ser260 | SLDSEDYsLSEEGQE | phosphorylation up-regulates | 19833129 | SIGNOR-188471 |
| TTK | MDM2 | Thr306 | LADYWKCtSCNEMNP | phosphorylation up-regulates activity | 26531827 | SIGNOR-279315 |
| AKT1 | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates activity | 11504915 | SIGNOR-116274 |
| PAK6 | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates activity | 23132866 | SIGNOR-276427 |
| AKT2 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 11504915 | SIGNOR-109732 |
| PPP1CB | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-248577 |
| PPP1CC | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-248504 |
| CSK | MDM2 | Tyr281 | EVYQVTVyQAGESDT | phosphorylation up-regulates activity | 25624478 | SIGNOR-279163 |
| CSK | MDM2 | Tyr302 | PEISLADyWKCTSCN | phosphorylation up-regulates activity | 25624478 | SIGNOR-279164 |
| TTK | MDM2 | Thr4 | tNMSVPTD | phosphorylation up-regulates activity | 26531827 | SIGNOR-279314 |
| PIM1 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 18467333 | SIGNOR-178615 |
| AKT2 | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates activity | 11504915 | SIGNOR-109736 |
| PPP1CA | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-248566 |
| CSNK1D | MDM2 | Ser253 | SVEFEVEsLDSEDYS | phosphorylation down-regulates | 20708156 | SIGNOR-167513 |
| PPM1D | MDM2 | Ser395 | SQESEDYsQPSTSSS | dephosphorylation down-regulates quantity by destabilization | 17936559 | SIGNOR-248324 |
| CSNK1D | MDM2 | Ser262 | DSEDYSLsEEGQELS | phosphorylation down-regulates | 12167711 | SIGNOR-91199 |
| PPM1D | MDM2 | Ser395 | SQESEDYsQPSTSSS | dephosphorylation up-regulates | 17936559 | SIGNOR-158328 |
| PP1 | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-264666 |
| CSNK1D | MDM2 | Ser121 | ESSDSGTsVSENRCH | phosphorylation down-regulates | 20708156 | SIGNOR-167501 |
| ATM | MDM2 | Ser395 | SQESEDYsQPSTSSS | phosphorylation down-regulates activity | 17936559 | SIGNOR-158324 |
| ABL1 | MDM2 | Tyr276 | SDEDDEVyQVTVYQA | phosphorylation down-regulates | 21081495 | SIGNOR-169699 |
| CHKA | MDM2 | – | phosphorylation down-regulates quantity by destabilization | 20708156 | SIGNOR-279606 | |
| ABL1 | MDM2 | Tyr405 | STSSSIIySSQEDVK | phosphorylation down-regulates | 21081495 | SIGNOR-169703 |
| AKT | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates activity | 15169778 | SIGNOR-244296 |
| PAK6 | MDM2 | Thr158 | HLVSRPStSSRRRAI | phosphorylation up-regulates activity | 23132866 | SIGNOR-276428 |
| ATM | MDM2 | Ser386 | DDKITQAsQSQESED | phosphorylation down-regulates activity | 19816404 | SIGNOR-188408 |
| BTK | MDM2 | – | phosphorylation down-regulates activity | 29290977 | SIGNOR-278330 | |
| AKT | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates activity | 11504915 | SIGNOR-244292 |
| CSNK1D | MDM2 | Ser269 | SEEGQELsDEDDEVY | phosphorylation down-regulates activity | 12167711 | SIGNOR-91191 |
| PIM1 | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates | 18467333 | SIGNOR-178619 |
| AKT1 | MDM2 | Ser188 | RKRHKSDsISLSFDE | phosphorylation up-regulates | 15169778 | SIGNOR-124953 |
| PLK1 | MDM2 | Ser260 | SLDSEDYsLSEEGQE | phosphorylation up-regulates | 12383858 | SIGNOR-94272 |
| CSNK1D | MDM2 | Ser118 | NQQESSDsGTSVSEN | phosphorylation down-regulates | 20708156 | SIGNOR-167497 |
| ABL1 | MDM2 | Tyr394 | QSQESEDySQPSTSS | phosphorylation down-regulates activity | 12110584 | SIGNOR-90512 |
| AKT1 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 15169778 | SIGNOR-124949 |
| CSNK1D | MDM2 | Ser262 | DSEDYSLsEEGQELS | phosphorylation down-regulates | 20708156 | SIGNOR-167517 |
| CSNK1D | MDM2 | – | phosphorylation down-regulates | 20708156 | SIGNOR-167520 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | MDM2 PSer429 | phosphorylation down-regulates ⊣ | MDM2 | 19816404 | SIGNOR-188412 |
| ATR | phosphorylation up-regulates → | MDM2 PSer407 | phosphorylation down-regulates ⊣ | MDM2 | 14654783 | SIGNOR-119546 |
| MAPKAPK2 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 15688025 | SIGNOR-133560 |
| DAPK3 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 15001356 | SIGNOR-123159 |
| PDXP | dephosphorylation down-regulates ⊣ | MDM2 PSer166 | dephosphorylation up-regulates → | MDM2 | 33414453 | SIGNOR-277151 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MDM2 PThr216 | dephosphorylation down-regulates ⊣ | MDM2 | 11983168 | SIGNOR-86736 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MDM2 PThr216 | dephosphorylation down-regulates ⊣ | MDM2 | 11983168 | SIGNOR-248636 |
| AKT | phosphorylation up-regulates → | MDM2 PSer188 | phosphorylation up-regulates → | MDM2 | 15169778 | SIGNOR-244300 |
| PIM | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-259434 |
| CSNK1D | phosphorylation up-regulates → | MDM2 PSer246 | phosphorylation down-regulates ⊣ | MDM2 | 20708156 | SIGNOR-167509 |
| CSNK1D | phosphorylation up-regulates → | MDM2 PSer253 | phosphorylation down-regulates ⊣ | MDM2 | 12167711 | SIGNOR-91195 |
| ATM | phosphorylation up-regulates → | MDM2 PSer395 | phosphorylation down-regulates ⊣ | MDM2 | 11331603 | SIGNOR-107256 |
| PIM | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-259433 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MDM2 PThr216 | dephosphorylation down-regulates ⊣ | MDM2 | 11983168 | SIGNOR-248593 |
| AKT1 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-116270 |
| ATM | phosphorylation up-regulates → | MDM2 PSer395 | phosphorylation down-regulates ⊣ | MDM2 | 12383858 | SIGNOR-94268 |
| PLK1 | phosphorylation up-regulates → | MDM2 PSer260 | phosphorylation up-regulates → | MDM2 | 19833129 | SIGNOR-188471 |
| TTK | phosphorylation up-regulates → | MDM2 PThr306 | phosphorylation up-regulates → | MDM2 | 26531827 | SIGNOR-279315 |
| AKT1 | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-116274 |
| PAK6 | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 23132866 | SIGNOR-276427 |
| AKT2 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-109732 |
| PPP1CB | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-248577 |
| PPP1CC | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-248504 |
| CSK | phosphorylation up-regulates → | MDM2 PTyr281 | phosphorylation up-regulates → | MDM2 | 25624478 | SIGNOR-279163 |
| CSK | phosphorylation up-regulates → | MDM2 PTyr302 | phosphorylation up-regulates → | MDM2 | 25624478 | SIGNOR-279164 |
| TTK | phosphorylation up-regulates → | MDM2 PThr4 | phosphorylation up-regulates → | MDM2 | 26531827 | SIGNOR-279314 |
| PIM1 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-178615 |
| AKT2 | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-109736 |
| PPP1CA | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-248566 |
| CSNK1D | phosphorylation up-regulates → | MDM2 PSer253 | phosphorylation down-regulates ⊣ | MDM2 | 20708156 | SIGNOR-167513 |
| PPM1D | dephosphorylation down-regulates ⊣ | MDM2 PSer395 | dephosphorylation up-regulates → | MDM2 | 17936559 | SIGNOR-248324 |
| CSNK1D | phosphorylation up-regulates → | MDM2 PSer262 | phosphorylation down-regulates ⊣ | MDM2 | 12167711 | SIGNOR-91199 |
| PPM1D | dephosphorylation down-regulates ⊣ | MDM2 PSer395 | dephosphorylation down-regulates ⊣ | MDM2 | 17936559 | SIGNOR-158328 |
| PP1 | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-264666 |
| CSNK1D | phosphorylation up-regulates → | MDM2 PSer121 | phosphorylation down-regulates ⊣ | MDM2 | 20708156 | SIGNOR-167501 |
| ATM | phosphorylation up-regulates → | MDM2 PSer395 | phosphorylation down-regulates ⊣ | MDM2 | 17936559 | SIGNOR-158324 |
| ABL1 | phosphorylation up-regulates → | MDM2 PTyr276 | phosphorylation down-regulates ⊣ | MDM2 | 21081495 | SIGNOR-169699 |
| ABL1 | phosphorylation up-regulates → | MDM2 PTyr405 | phosphorylation down-regulates ⊣ | MDM2 | 21081495 | SIGNOR-169703 |
| AKT | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 15169778 | SIGNOR-244296 |
| PAK6 | phosphorylation up-regulates → | MDM2 PThr158 | phosphorylation up-regulates → | MDM2 | 23132866 | SIGNOR-276428 |
| ATM | phosphorylation up-regulates → | MDM2 PSer386 | phosphorylation down-regulates ⊣ | MDM2 | 19816404 | SIGNOR-188408 |
| AKT | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-244292 |
| CSNK1D | phosphorylation up-regulates → | MDM2 PSer269 | phosphorylation down-regulates ⊣ | MDM2 | 12167711 | SIGNOR-91191 |
| PIM1 | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-178619 |
| AKT1 | phosphorylation up-regulates → | MDM2 PSer188 | phosphorylation up-regulates → | MDM2 | 15169778 | SIGNOR-124953 |
| PLK1 | phosphorylation up-regulates → | MDM2 PSer260 | phosphorylation up-regulates → | MDM2 | 12383858 | SIGNOR-94272 |
| CSNK1D | phosphorylation up-regulates → | MDM2 PSer118 | phosphorylation down-regulates ⊣ | MDM2 | 20708156 | SIGNOR-167497 |
| ABL1 | phosphorylation up-regulates → | MDM2 PTyr394 | phosphorylation down-regulates ⊣ | MDM2 | 12110584 | SIGNOR-90512 |
| AKT1 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 15169778 | SIGNOR-124949 |
| CSNK1D | phosphorylation up-regulates → | MDM2 PSer262 | phosphorylation down-regulates ⊣ | MDM2 | 20708156 | SIGNOR-167517 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → down-regulates activity | MDM2 | SIGNOR-188412 |
| ATR | phosphorylation → down-regulates activity | MDM2 | SIGNOR-119546 |
| MAPKAPK2 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-133560 |
| DAPK3 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-123159 |
| PDXP | dephosphorylation → down-regulates activity | MDM2 | SIGNOR-277151 |
| PPP2CB | dephosphorylation → up-regulates | MDM2 | SIGNOR-86736 |
| PPP2CA | dephosphorylation → up-regulates activity | MDM2 | SIGNOR-248636 |
| AKT | phosphorylation → up-regulates activity | MDM2 | SIGNOR-244300 |
| PIM | phosphorylation → up-regulates | MDM2 | SIGNOR-259434 |
| HIPK2 | phosphorylation → down-regulates activity | MDM2 | SIGNOR-279465 |
| CSNK1D | phosphorylation down-regulates | MDM2 | SIGNOR-167509 |
| CSNK1D | phosphorylation down-regulates | MDM2 | SIGNOR-91195 |
| ATM | phosphorylation → down-regulates activity | MDM2 | SIGNOR-107256 |
| PIM | phosphorylation → up-regulates | MDM2 | SIGNOR-259433 |
| PPP2CB | dephosphorylation → up-regulates activity | MDM2 | SIGNOR-248593 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-116270 |
| ATM | phosphorylation → down-regulates activity | MDM2 | SIGNOR-94268 |
| PLK1 | phosphorylation → up-regulates | MDM2 | SIGNOR-188471 |
| TTK | phosphorylation → up-regulates activity | MDM2 | SIGNOR-279315 |
| AKT1 | phosphorylation → up-regulates activity | MDM2 | SIGNOR-116274 |
| PAK6 | phosphorylation → up-regulates activity | MDM2 | SIGNOR-276427 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-109732 |
| PPP1CB | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-248577 |
| PPP1CC | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-248504 |
| CSK | phosphorylation → up-regulates activity | MDM2 | SIGNOR-279163 |
| CSK | phosphorylation → up-regulates activity | MDM2 | SIGNOR-279164 |
| TTK | phosphorylation → up-regulates activity | MDM2 | SIGNOR-279314 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-178615 |
| AKT2 | phosphorylation → up-regulates activity | MDM2 | SIGNOR-109736 |
| PPP1CA | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-248566 |
| CSNK1D | phosphorylation down-regulates | MDM2 | SIGNOR-167513 |
| PPM1D | dephosphorylation down-regulates quantity by destabilization | MDM2 | SIGNOR-248324 |
| CSNK1D | phosphorylation down-regulates | MDM2 | SIGNOR-91199 |
| PPM1D | dephosphorylation → up-regulates | MDM2 | SIGNOR-158328 |
| PP1 | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-264666 |
| CSNK1D | phosphorylation down-regulates | MDM2 | SIGNOR-167501 |
| ATM | phosphorylation → down-regulates activity | MDM2 | SIGNOR-158324 |
| ABL1 | phosphorylation down-regulates | MDM2 | SIGNOR-169699 |
| CHKA | phosphorylation down-regulates quantity by destabilization | MDM2 | SIGNOR-279606 |
| ABL1 | phosphorylation down-regulates | MDM2 | SIGNOR-169703 |
| AKT | phosphorylation → up-regulates activity | MDM2 | SIGNOR-244296 |
| PAK6 | phosphorylation → up-regulates activity | MDM2 | SIGNOR-276428 |
| ATM | phosphorylation → down-regulates activity | MDM2 | SIGNOR-188408 |
| BTK | phosphorylation → down-regulates activity | MDM2 | SIGNOR-278330 |
| AKT | phosphorylation → up-regulates activity | MDM2 | SIGNOR-244292 |
| CSNK1D | phosphorylation → down-regulates activity | MDM2 | SIGNOR-91191 |
| PIM1 | phosphorylation → up-regulates | MDM2 | SIGNOR-178619 |
| AKT1 | phosphorylation → up-regulates | MDM2 | SIGNOR-124953 |
| PLK1 | phosphorylation → up-regulates | MDM2 | SIGNOR-94272 |
| CSNK1D | phosphorylation down-regulates | MDM2 | SIGNOR-167497 |
| ABL1 | phosphorylation → down-regulates activity | MDM2 | SIGNOR-90512 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-124949 |
| CSNK1D | phosphorylation down-regulates | MDM2 | SIGNOR-167517 |
| CSNK1D | phosphorylation down-regulates | MDM2 | SIGNOR-167520 |