Summary

Name MDM2
Full Name E3 ubiquitin-protein ligase Mdm2
Synonyms Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2
Primary ID Q00987
Links - -
Type protein
Relations 68
Pathways Cell cycle: G1/S phase transition, Malignant Melanoma, Acute Myeloid Leukemia, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Prostate Cancer, AML-NP1, AML1-ETO, AML_miRNA
Inhibitors Serdemetan; nutlin-3A
Function E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation MDM2 0.14
Publications: 9 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MDM2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MDM2 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MDM2 0.20
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MDM2
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation MDM2 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MDM2
Publications: 3 Organism: Homo Sapiens
Tissue: Kidney
Pathways:Acute Myeloid Leukemia, Cell cycle: G1/S phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer
+ up-regulates img/direct-activation.png phosphorylation MDM2 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MDM2 0.18
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MDM2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation MDM2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation MDM2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation MDM2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MDM2 0.31
Publications: 5 Organism: Homo Sapiens, In Vitro
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png dephosphorylation MDM2 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation MDM2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MDM2 0.19
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates activity img/direct-activation.png dephosphorylation MDM2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation MDM2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png dephosphorylation MDM2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MDM2 0.15
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png phosphorylation MDM2 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TP53
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO, AML_miRNA, AML-NP1, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MDM2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML1-ETO, AML_miRNA, AML-NP1, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MDM2 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MDM2 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ubiquitination NOTCH1 0.07
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TP73 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MDM2 0.07
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization MDM2
Publications: 1 Organism: Homo Sapiens
Pathways:AML1-ETO, AML-NP1, Cell cycle: G1/S phase transition, Luminal Breast Cancer, Malignant Melanoma
+ down-regulates quantity by repression img/indirect_inhibition.png unknown CDKN1A 0.61
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ down-regulates img/direct_inhibition.png binding MDM2 0.20
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MDM2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deubiquitination MDM2 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination MDM4 0.85
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MDM2 0.24
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MDM2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png stabilization MDM2 0.85
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MDM2 0.05
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown MDM2 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MDM2 0.19
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CDKN2AIP 0.05
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination NOTCH4 0.05
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MDM2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML_miRNA
+ down-regulates img/direct_inhibition.png ubiquitination NUMB 0.20
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EP300 0.29
Publications: 1 Organism: Homo Sapiens