| + |
CSNK1D | down-regulates 
phosphorylation
|
MDM2 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167497 |
Ser118 |
NQQESSDsGTSVSEN |
Homo sapiens |
|
| pmid |
sentence |
| 20708156 |
Phosphorylation by casein kinase i promotes the turnover of the mdm2 oncoprotein via the scf(beta-trcp) ubiquitin ligase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167501 |
Ser121 |
ESSDSGTsVSENRCH |
Homo sapiens |
|
| pmid |
sentence |
| 20708156 |
Phosphorylation by casein kinase i promotes the turnover of the mdm2 oncoprotein via the scf(beta-trcp) ubiquitin ligase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167505 |
Ser166 |
SSRRRAIsETEENSD |
Homo sapiens |
|
| pmid |
sentence |
| 20708156 |
Phosphorylation by casein kinase i promotes the turnover of the mdm2 oncoprotein via the scf(beta-trcp) ubiquitin ligase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167509 |
Ser246 |
DSVSDQFsVEFEVES |
Homo sapiens |
|
| pmid |
sentence |
| 20708156 |
Cki phosphorylates mdm2 at multiple sites to trigger mdm2/beta-trcp1 interactionbeta-trcp promotes mdm2 turnover and ubiquitination |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167513 |
Ser253 |
SVEFEVEsLDSEDYS |
Homo sapiens |
|
| pmid |
sentence |
| 20708156 |
Cki phosphorylates mdm2 at multiple sites to trigger mdm2/beta-trcp1 interactionbeta-trcp promotes mdm2 turnover and ubiquitination |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-91195 |
Ser253 |
SVEFEVEsLDSEDYS |
Homo sapiens |
|
| pmid |
sentence |
| 12167711 |
Hypophosphorylation of mdm2 augments p53 stability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-91199 |
Ser262 |
DSEDYSLsEEGQELS |
Homo sapiens |
|
| pmid |
sentence |
| 12167711 |
Hypophosphorylation of mdm2 augments p53 stability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167517 |
Ser262 |
DSEDYSLsEEGQELS |
Homo sapiens |
|
| pmid |
sentence |
| 20708156 |
Cki phosphorylates mdm2 at multiple sites to trigger mdm2/beta-trcp1 interactionbeta-trcp promotes mdm2 turnover and ubiquitination |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167520 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20708156 |
Phosphorylation by casein kinase i promotes the turnover of the mdm2 oncoprotein via the scf(beta-trcp) ubiquitin ligase. |
|
| Publications: |
9 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates activity 
phosphorylation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116270 |
Ser166 |
SSRRRAIsETEENSD |
Homo sapiens |
|
| pmid |
sentence |
| 11504915 |
Mitogen-induced activation of phosphatidylinositol 3-kinase (pi3-kinase) and its downstream target, the akt/pkb serine-threonine kinase, results in phosphorylation of mdm2 on serine 166 and serine 186. Phosphorylation on these sites is necessary for translocation of mdm2 from the cytoplasm into the nucleus.Both akt expression and serum treatment induced phosphorylation of mdm2 at ser186. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116274 |
Ser186 |
RQRKRHKsDSISLSF |
Homo sapiens |
|
| pmid |
sentence |
| 11504915 |
Mitogen-induced activation of phosphatidylinositol 3-kinase (pi3-kinase) and its downstream target, the akt/pkb serine-threonine kinase, results in phosphorylation of mdm2 on serine 166 and serine 186. Phosphorylation on these sites is necessary for translocation of mdm2 from the cytoplasm into the nucleus.Both akt expression and serum treatment induced phosphorylation of mdm2 at ser186. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT2 | up-regulates activity
phosphorylation
|
MDM2 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109732 |
Ser166 |
SSRRRAIsETEENSD |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 11504915 |
Mitogen-induced activation of phosphatidylinositol 3-kinase (pi3-kinase) and its downstream target, the akt/pkb serine-threonine kinase, results in phosphorylation of mdm2 on serine 166 and serine 186. Phosphorylation on these sites is necessary for translocation of mdm2 from the cytoplasm into the nucleus.. Both akt expression and serum treatment induced phosphorylation of mdm2 at ser186. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109736 |
Ser186 |
RQRKRHKsDSISLSF |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 11504915 |
Mitogen-induced activation of phosphatidylinositol 3-kinase (pi3-kinase) and its downstream target, the akt/pkb serine-threonine kinase, results in phosphorylation of mdm2 on serine 166 and serine 186. Phosphorylation on these sites is necessary for translocation of mdm2 from the cytoplasm into the nucleus.. Both akt expression and serum treatment induced phosphorylation of mdm2 at ser186. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PIM1 | up-regulates
phosphorylation
|
MDM2 |
0.20 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178615 |
Ser166 |
SSRRRAIsETEENSD |
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 18467333 |
Additionally, the pim kinases phosphorylate mdm2 in vitro and in cultured cells at ser166 and ser186, two previously identified targets of other signaling pathways, including akt. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178619 |
Ser186 |
RQRKRHKsDSISLSF |
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 18467333 |
Additionally, the pim kinases phosphorylate mdm2 in vitro and in cultured cells at ser166 and ser186, two previously identified targets of other signaling pathways, including akt. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates
phosphorylation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124949 |
Ser166 |
SSRRRAIsETEENSD |
Homo sapiens |
|
| pmid |
sentence |
| 15169778 |
Stabilization of mdm2 via decreased ubiquitination is mediated by protein kinase b/akt-dependent phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124953 |
Ser188 |
RKRHKSDsISLSFDE |
Homo sapiens |
|
| pmid |
sentence |
| 15169778 |
Stabilization of mdm2 via decreased ubiquitination is mediated by protein kinase b/akt-dependent phosphorylationhere we show that pkb inhibits mdm2 self-ubiquitination via phosphorylation of mdm2 on ser(166) and ser(188) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
MAPKAPK2 | up-regulates
phosphorylation
|
MDM2 |
0.06 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133560 |
Ser166 |
SSRRRAIsETEENSD |
Homo sapiens |
|
| pmid |
sentence |
| 15688025 |
Hdm2 phosphorylation by mapkap kinase 2 enhances hdm2 activity and promote the degradation of p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | up-regulates activity
phosphorylation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244296 |
Ser166 |
SSRRRAIsETEENSD |
Homo sapiens |
|
| pmid |
sentence |
| 15169778 |
Stabilization of mdm2 via decreased ubiquitination is mediated by protein kinase b/akt-dependent phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244292 |
Ser186 |
RQRKRHKsDSISLSF |
Homo sapiens |
|
| pmid |
sentence |
| 11504915 |
Mitogen-induced activation of phosphatidylinositol 3-kinase (pi3-kinase) and its downstream target, the akt/pkb serine-threonine kinase, results in phosphorylation of mdm2 on serine 166 and serine 186. Phosphorylation on these sites is necessary for translocation of mdm2 from the cytoplasm into the nucleus.Both akt expression and serum treatment induced phosphorylation of mdm2 at ser186. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244300 |
Ser188 |
RKRHKSDsISLSFDE |
Homo sapiens |
|
| pmid |
sentence |
| 15169778 |
Stabilization of mdm2 via decreased ubiquitination is mediated by protein kinase b/akt-dependent phosphorylationhere we show that pkb inhibits mdm2 self-ubiquitination via phosphorylation of mdm2 on ser(166) and ser(188) |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| Pathways: | Acute Myeloid Leukemia, Cell cycle: G1/S phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer |
| + |
DAPK3 | up-regulates
phosphorylation
|
MDM2 |
0.11 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123159 |
Ser166 |
SSRRRAIsETEENSD |
Homo sapiens |
|
| pmid |
sentence |
| 15001356 |
Zip kinase was able to phosphorylate mdm2 at ser166, a site previously reported to be modified by akt kinase, thus demonstrating that zip kinase is a bona fide mdm2-binding protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates
phosphorylation
|
MDM2 |
0.18 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188471 |
Ser260 |
SLDSEDYsLSEEGQE |
Homo sapiens |
|
| pmid |
sentence |
| 19833129 |
Polo-like kinase-1 phosphorylates mdm2 at ser260 and stimulates mdm2-mediated p53 turnover. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94272 |
Ser260 |
SLDSEDYsLSEEGQE |
Homo sapiens |
|
| pmid |
sentence |
| 12383858 |
Here we show that the oncogenic and cell cycle-regulatory protein kinase, polo-like kinase-1 (plk1), phosphorylates mdm2 at one of these residues, ser260, and stimulates mdm2-mediated turnover of p53. These data are consistent with the idea that deregulation of plk1 during tumourigenesis may help suppress p53 function. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK1D | down-regulates activity
phosphorylation
|
MDM2 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-91191 |
Ser269 |
SEEGQELsDEDDEVY |
Homo sapiens |
|
| pmid |
sentence |
| 12167711 |
Hypophosphorylation of mdm2 augments p53 stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1CA | up-regulates quantity by stabilization
dephosphorylation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248566 |
Ser370 |
KKTIVNDsRESCVEE |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 23277204 |
Three phosphorylation sites identified are Ser342, Ser367, and Ser403. In the present study, we identify protein phosphatase 1 (PP1) as a negative regulator in the p53 signaling pathway. PP1 directly interacts with Mdmx and specifically dephosphorylates Mdmx at Ser367. The dephosphorylation of Mdmx increases its stability and thereby inhibits p53 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1CC | up-regulates quantity by stabilization
dephosphorylation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248504 |
Ser370 |
KKTIVNDsRESCVEE |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 23277204 |
Three phosphorylation sites identified are Ser342, Ser367, and Ser403. In the present study, we identify protein phosphatase 1 (PP1) as a negative regulator in the p53 signaling pathway. PP1 directly interacts with Mdmx and specifically dephosphorylates Mdmx at Ser367. The dephosphorylation of Mdmx increases its stability and thereby inhibits p53 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1CB | up-regulates quantity by stabilization
dephosphorylation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248577 |
Ser370 |
KKTIVNDsRESCVEE |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 23277204 |
Three phosphorylation sites identified are Ser342, Ser367, and Ser403. In the present study, we identify protein phosphatase 1 (PP1) as a negative regulator in the p53 signaling pathway. PP1 directly interacts with Mdmx and specifically dephosphorylates Mdmx at Ser367. The dephosphorylation of Mdmx increases its stability and thereby inhibits p53 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATM | down-regulates activity
phosphorylation
|
MDM2 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188408 |
Ser386 |
DDKITQAsQSQESED |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19816404 |
These data indicate that atm is responsible for directly phosphorylating s386 and s429 after dna damagemdm2 phosphorylation inhibits p53 poly ubiquitination |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158324 |
Ser395 |
SQESEDYsQPSTSSS |
Homo sapiens |
SAOS-2 Cell |
| pmid |
sentence |
| 17936559 |
Dephosphorylation stabilizes mdm2 and increases its affinity for p53, inducing p53 degredation. ;phosphorylated s260 and s395 ands260d and s395d mutant peptides inhibited binding of binding of a specific monoclonal antibody raised to mdm2. Phosphorylation of mdm2 regulates p53 degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107256 |
Ser395 |
SQESEDYsQPSTSSS |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 11331603 |
Atm phosphorylates mdm2 on s395 in vitro. Moreover, s395 appears to be phosphorylated in an atm-dependent manner in vivo the precise mechanism through which s395 phosphorylation attenuates mdm2 function is unclear. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94268 |
Ser395 |
SQESEDYsQPSTSSS |
in vitro |
|
| pmid |
sentence |
| 12383858 |
Dephosphorylation stabilizes mdm2 and increases its affinity for p53, inducing p53 degredation. ;phosphorylated s260 and s395 ands260d and s395d mutant peptides inhibited binding of binding of a specific monoclonal antibody raised to mdm2. Phosphorylation of mdm2 regulates p53 degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188412 |
Ser429 |
KEESVESsLPLNAIE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19816404 |
These data indicate that atm is responsible for directly phosphorylating s386 and s429 after dna damagemdm2 phosphorylation inhibits p53 poly ubiquitination |
|
| Publications: |
5 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition |
| + |
PPM1D | up-regulates
dephosphorylation
|
MDM2 |
0.13 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158328 |
Ser395 |
SQESEDYsQPSTSSS |
Homo sapiens |
|
| pmid |
sentence |
| 17936559 |
Wip1 interacts with and dephosphorylates mdm2 at serine 395, a site phosphorylated by the atm kinase. Dephosphorylated mdm2 has increased stability and affinity for p53, facilitating p53 ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1D | down-regulates quantity by destabilization
dephosphorylation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248324 |
Ser395 |
SQESEDYsQPSTSSS |
Homo sapiens |
|
| pmid |
sentence |
| 17936559 |
Here we show that the wild-type p53-induced phosphatase 1 (Wip1), or PPM1D, downregulates p53 protein levels by stabilizing Mdm2 and facilitating its access to p53. Wip1 interacts with and dephosphorylates Mdm2 at serine 395, a site phosphorylated by the ATM kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATR | down-regulates activity
phosphorylation
|
MDM2 |
0.19 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119546 |
Ser407 |
SSSIIYSsQEDVKEF |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 14654783 |
We found that a major kinase responsible for s407 phosphorylation is atrs407 phosphorylation of mdm2 by atr reduces mdm2-dependent export of p53 from nuclei to cytoplasm. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition |
| + |
PPP2CA | up-regulates activity
dephosphorylation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248636 |
Thr216 |
RSSSSEStGTPSNPD |
Mus musculus |
|
| pmid |
sentence |
| 11983168 |
cyclin G also binds in vivo and in vitro to Mdm2 and markedly stimulates the ability of PP2A to dephosphorylate Mdm2 at T216. Consistent with these data, cyclin G null cells have both Mdm2 that is hyperphosphorylated at T216 and markedly higher levels of p53 protein when compared to wild-type cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPP2CB | up-regulates activity
dephosphorylation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248593 |
Thr216 |
RSSSSEStGTPSNPD |
Mus musculus |
|
| pmid |
sentence |
| 11983168 |
cyclin G also binds in vivo and in vitro to Mdm2 and markedly stimulates the ability of PP2A to dephosphorylate Mdm2 at T216. Consistent with these data, cyclin G null cells have both Mdm2 that is hyperphosphorylated at T216 and markedly higher levels of p53 protein when compared to wild-type cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPP2CB | up-regulates
dephosphorylation
|
MDM2 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86736 |
Thr216 |
RSSSSEStGTPSNPD |
Homo sapiens |
|
| pmid |
sentence |
| 11983168 |
Cyclin g also binds in vivo and in vitro to mdm2 and markedly stimulates the ability of pp2a to dephosphorylate mdm2 at t216. Our data imply that the function of cyclin g is to serve as a negative regulator of p53 by activating mdm2 through dephosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | down-regulates
phosphorylation
|
MDM2 |
0.15 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169699 |
Tyr276 |
SDEDDEVyQVTVYQA |
Homo sapiens |
|
| pmid |
sentence |
| 21081495 |
Mdm2 has three known c-abl phosphorylation sites (tyr276, tyr394, and tyr405)these data show that c-abl is important for reducing mdm2 and mdmx protein levels after genotoxic stress and suggest another cellular mechanism for the stabilization and activation of p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169703 |
Tyr405 |
STSSSIIySSQEDVK |
Homo sapiens |
|
| pmid |
sentence |
| 21081495 |
Mdm2 has three known c-abl phosphorylation sites (tyr276, tyr394, and tyr405)these data show that c-abl is important for reducing mdm2 and mdmx protein levels after genotoxic stress and suggest another cellular mechanism for the stabilization and activation of p53. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
ABL1 | down-regulates activity
phosphorylation
|
MDM2 |
0.15 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90512 |
Tyr394 |
QSQESEDySQPSTSS |
Homo sapiens |
|
| pmid |
sentence |
| 12110584 |
C-abl binds and phosphorylates mdm2 in vivo and in vitro;phosphorylation of mdm2 by c-abl impairs the inhibition of p53 by mdm2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
MDM2 | down-regulates quantity by destabilization
ubiquitination
|
TP53 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80528 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10935507 |
Many posttranslational modifications of p53, such as phosphorylation, dephosphorylation, acetylation and ribosylation, have been shown to occur following cellular stress. Some of these modifications may activate the p53 protein, interfere with MDM2 binding and/or dictate cellular localization of p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196116 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 22337874 |
The E3 ubiquitin ligase, MDM2, uses a dual-site mechanism to ubiquitinate and degrade the tumor suppressor protein p53, involving interactions with the N-terminal hydrophobic pocket and the acidic domain of MDM2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199371 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23150757 |
Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO, AML_miRNA, AML-NP1, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer |
| + |
TP53 | up-regulates quantity by expression 
transcriptional regulation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34962 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 7958853 |
The p53 tumor suppressor protein trans-activates mdm2 itself, which is therefore considered a component of a p53 negative feedback loop. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO, AML_miRNA, AML-NP1, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer |
| + |
BCL3 | up-regulates quantity by expression
transcriptional regulation
|
MDM2 |
0.06 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143403 |
|
|
Homo sapiens |
B-lymphocyte, Lymphoma Cell |
| pmid |
sentence |
| 16384933 |
One mechanism by which this inhibition occurs is through bcl-3-mediated induction of the p53 inhibitor hdm2. Both stable and transient overexpression of bcl-3 leads to increased hdm2 expression, and small interfering rna (sirna)-mediated knockdown of bcl-3 blocks expression of hdm2. ( articolo-abstract) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELF4 | up-regulates quantity by expression
transcriptional regulation
|
MDM2 |
0.12 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185490 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19380490 |
We found that elf4/mef activates mdm2 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDM2 | up-regulates
ubiquitination
|
NOTCH1 |
0.07 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200197 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23252402 |
Although the interaction between notch1 and mdm2 results in ubiquitination of notch1, this does not result in degradation of notch1, but instead leads to activation of the intracellular domain of notch1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDM2 | down-regulates activity
binding
|
TP73 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255470 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17700533 |
Since HDM2, a key negative regulator of p53, also binds to and inhibits p73, we asked whether p73 could mediate Nutlin-3-induced apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFAP4 | down-regulates quantity by repression 
transcriptional regulation
|
MDM2 |
0.07 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226596 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 19505873 |
AP-4 Mediates E-box-dependent Complex Formation for Transcriptional Repression of HDM2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN2A | down-regulates activity
relocalization
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192697 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 23416275 |
We propose that p14(arf) increases the binding of p53-mdm2 complexes to chromatin, thereby limiting the access of protein deacetylases to p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AML1-ETO, AML-NP1, Cell cycle: G1/S phase transition, Luminal Breast Cancer, Malignant Melanoma |
| + |
MDM2 | down-regulates quantity by repression
unknown
|
CDKN1A |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160977 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 18292944 |
Overexpression of hdm2 resulted in a decrease in the level of p21waf1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition |
| + |
NUMB | down-regulates
binding
|
MDM2 |
0.20 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20940030 |
Numb interacts with mdm2, and inhibits its ubiquitin-ligase function on tp53 (which in itself is inhibitory for tp53), thus numb activates (b) tp53 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Serdemetan | down-regulates
chemical inhibition
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-193504 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP7 | up-regulates
deubiquitination
|
MDM2 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139450 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16082221 |
Subsequently, hausp was shown to deubiquitinate mdm2 and mdmx, thereby stabilizing these proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDM2 | down-regulates
ubiquitination
|
MDM4 |
0.85 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144970 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16511560 |
The mdm2 homolog mdmx is an important regulator of p53 during mouse embryonic development. Dna damage promotes mdmx phosphorylation, nuclear translocation, and degradation by mdm2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DAXX | up-regulates
binding
|
MDM2 |
0.24 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200892 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23405218 |
The optimal function of mdm2 requires daxx, which stabilizes mdm2 through the deubiquitinase hausp/usp7 and also directly promotes mdm2's ubiquitin ligase activity towards p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
nutlin-3A | down-regulates
chemical inhibition
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-194874 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDM4 | up-regulates
stabilization
|
MDM2 |
0.85 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134391 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15735705 |
Mdm2 and mdmx function as cellular regulators of the p53 tumor suppressor protein. Intriguingly, the activities of these proteins are interdependent;mdmx stabilizes mdm2, enabling its activities towards p53 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN2AIP | down-regulates quantity by repression
transcriptional regulation
|
MDM2 |
0.05 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160971 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18292944 |
Carf interacts with hdm2 and undergoes degradation by an hdm2-dependent proteasome pathway, and ii) it acts as a transcriptional repressor of hdm2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FHIT | down-regulates
unknown
|
MDM2 |
0.12 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127610 |
|
|
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 15313915 |
We found that this synergistic inhibition of tumor cell growth corresponded with the fhit-mediated inactivation of mdm2, which thereby blocked the association of mdm2 with p53, thus stabilizing the p53 protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM28 | up-regulates activity
binding
|
MDM2 |
0.19 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240405 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16107876 |
we present evidence that MDM2 interacts with the nuclear corepressor KAP1. MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDM2 | down-regulates
ubiquitination
|
CDKN2AIP |
0.05 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160974 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18292944 |
Carf interacts with hdm2 and is ubiquitinated and negatively regulated by hdm2 by proteasome-dependent degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDM2 | down-regulates
ubiquitination
|
NOTCH4 |
0.05 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172826 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21402876 |
We demonstrate that the intracellular domain of notch 4 is targeted for ubiquitylation and hence degradation by the ubiquitin ligase mdm2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168296 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 20921405 |
Nf-kb activation following t-cell receptor engagement induces the expression of mdm2 through interaction with nf-kb sites in its p1 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML_miRNA |
| + |
MDM2 | down-regulates
ubiquitination
|
NUMB |
0.20 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99497 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 12646252 |
These data strongly suggest thatmdm2functions as the ubiquitin ligase toward hnumb and that it induces its degradation in intact cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDM2 | down-regulates
binding
|
EP300 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84077 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11070080 |
Mdm2, a negative-feedback regulator of p53, inhibited p300-mediated p53 acetylation by complexing with these two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
MDM2
- 
- 