| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | MDM2 | Tyr394 | QSQESEDySQPSTSS | phosphorylation down-regulates activity | 12110584 | SIGNOR-90512 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | MDM2 PTyr394 | phosphorylation down-regulates ⊣ | MDM2 | 12110584 | SIGNOR-90512 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL1 | phosphorylation → down-regulates activity | MDM2 | SIGNOR-90512 |