| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates | 18467333 | SIGNOR-178619 |
| PIM | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates | 18467333 | SIGNOR-259434 |
| AKT1 | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates activity | 11504915 | SIGNOR-116274 |
| PAK6 | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates activity | 23132866 | SIGNOR-276427 |
| AKT2 | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates activity | 11504915 | SIGNOR-109736 |
| AKT | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates activity | 11504915 | SIGNOR-244292 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-178619 |
| PIM | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-259434 |
| AKT1 | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-116274 |
| PAK6 | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 23132866 | SIGNOR-276427 |
| AKT2 | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-109736 |
| AKT | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-244292 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIM1 | phosphorylation → up-regulates | MDM2 | SIGNOR-178619 |
| PIM | phosphorylation → up-regulates | MDM2 | SIGNOR-259434 |
| AKT1 | phosphorylation → up-regulates activity | MDM2 | SIGNOR-116274 |
| PAK6 | phosphorylation → up-regulates activity | MDM2 | SIGNOR-276427 |
| AKT2 | phosphorylation → up-regulates activity | MDM2 | SIGNOR-109736 |
| AKT | phosphorylation → up-regulates activity | MDM2 | SIGNOR-244292 |
