| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 11504915 | SIGNOR-116270 |
| AKT2 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 11504915 | SIGNOR-109732 |
| PIM1 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 18467333 | SIGNOR-178615 |
| AKT | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates activity | 15169778 | SIGNOR-244296 |
| AKT1 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 15169778 | SIGNOR-124949 |
| MAPKAPK2 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 15688025 | SIGNOR-133560 |
| DAPK3 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 15001356 | SIGNOR-123159 |
| PDXP | MDM2 | Ser166 | SSRRRAIsETEENSD | dephosphorylation down-regulates activity | 33414453 | SIGNOR-277151 |
| PIM | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates | 18467333 | SIGNOR-259433 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-116270 |
| AKT2 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-109732 |
| PIM1 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-178615 |
| AKT | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 15169778 | SIGNOR-244296 |
| AKT1 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 15169778 | SIGNOR-124949 |
| MAPKAPK2 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 15688025 | SIGNOR-133560 |
| DAPK3 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 15001356 | SIGNOR-123159 |
| PDXP | dephosphorylation down-regulates ⊣ | MDM2 PSer166 | dephosphorylation up-regulates → | MDM2 | 33414453 | SIGNOR-277151 |
| PIM | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-259433 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-116270 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-109732 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-178615 |
| AKT | phosphorylation → up-regulates activity | MDM2 | SIGNOR-244296 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-124949 |
| MAPKAPK2 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-133560 |
| DAPK3 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-123159 |
| PDXP | dephosphorylation → down-regulates activity | MDM2 | SIGNOR-277151 |
| PIM | phosphorylation → up-regulates | MDM2 | SIGNOR-259433 |
