| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | MDM2 | Ser386 | DDKITQAsQSQESED | phosphorylation down-regulates activity | 19816404 | SIGNOR-188408 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | MDM2 PSer386 | phosphorylation down-regulates ⊣ | MDM2 | 19816404 | SIGNOR-188408 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → down-regulates activity | MDM2 | SIGNOR-188408 |