| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | MDM2 | Ser395 | SQESEDYsQPSTSSS | dephosphorylation up-regulates | 17936559 | SIGNOR-158328 |
| ATM | MDM2 | Ser395 | SQESEDYsQPSTSSS | phosphorylation down-regulates activity | 17936559 | SIGNOR-158324 |
| ATM | MDM2 | Ser395 | SQESEDYsQPSTSSS | phosphorylation down-regulates activity | 11331603 | SIGNOR-107256 |
| ATM | MDM2 | Ser395 | SQESEDYsQPSTSSS | phosphorylation down-regulates activity | 12383858 | SIGNOR-94268 |
| PPM1D | MDM2 | Ser395 | SQESEDYsQPSTSSS | dephosphorylation down-regulates quantity by destabilization | 17936559 | SIGNOR-248324 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | MDM2 PSer395 | dephosphorylation down-regulates ⊣ | MDM2 | 17936559 | SIGNOR-158328 |
| ATM | phosphorylation up-regulates → | MDM2 PSer395 | phosphorylation down-regulates ⊣ | MDM2 | 17936559 | SIGNOR-158324 |
| ATM | phosphorylation up-regulates → | MDM2 PSer395 | phosphorylation down-regulates ⊣ | MDM2 | 11331603 | SIGNOR-107256 |
| ATM | phosphorylation up-regulates → | MDM2 PSer395 | phosphorylation down-regulates ⊣ | MDM2 | 12383858 | SIGNOR-94268 |
| PPM1D | dephosphorylation down-regulates ⊣ | MDM2 PSer395 | dephosphorylation up-regulates → | MDM2 | 17936559 | SIGNOR-248324 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation → up-regulates | MDM2 | SIGNOR-158328 |
| ATM | phosphorylation → down-regulates activity | MDM2 | SIGNOR-158324 |
| ATM | phosphorylation → down-regulates activity | MDM2 | SIGNOR-107256 |
| ATM | phosphorylation → down-regulates activity | MDM2 | SIGNOR-94268 |
| PPM1D | dephosphorylation down-regulates quantity by destabilization | MDM2 | SIGNOR-248324 |
