| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | MDM2 | Ser407 | SSSIIYSsQEDVKEF | phosphorylation down-regulates activity | 14654783 | SIGNOR-119546 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | phosphorylation up-regulates → | MDM2 PSer407 | phosphorylation down-regulates ⊣ | MDM2 | 14654783 | SIGNOR-119546 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATR | phosphorylation → down-regulates activity | MDM2 | SIGNOR-119546 |
