| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | MDM2 | Ser253 | SVEFEVEsLDSEDYS | phosphorylation down-regulates | 20708156 | SIGNOR-167513 |
| CSNK1D | MDM2 | Ser253 | SVEFEVEsLDSEDYS | phosphorylation down-regulates | 12167711 | SIGNOR-91195 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | phosphorylation up-regulates → | MDM2 PSer253 | phosphorylation down-regulates ⊣ | MDM2 | 20708156 | SIGNOR-167513 |
| CSNK1D | phosphorylation up-regulates → | MDM2 PSer253 | phosphorylation down-regulates ⊣ | MDM2 | 12167711 | SIGNOR-91195 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1D | phosphorylation down-regulates | MDM2 | SIGNOR-167513 |
| CSNK1D | phosphorylation down-regulates | MDM2 | SIGNOR-91195 |
