| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | MDM2 | Ser260 | SLDSEDYsLSEEGQE | phosphorylation up-regulates | 19833129 | SIGNOR-188471 |
| PLK1 | MDM2 | Ser260 | SLDSEDYsLSEEGQE | phosphorylation up-regulates | 12383858 | SIGNOR-94272 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | MDM2 PSer260 | phosphorylation up-regulates → | MDM2 | 19833129 | SIGNOR-188471 |
| PLK1 | phosphorylation up-regulates → | MDM2 PSer260 | phosphorylation up-regulates → | MDM2 | 12383858 | SIGNOR-94272 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → up-regulates | MDM2 | SIGNOR-188471 |
| PLK1 | phosphorylation → up-regulates | MDM2 | SIGNOR-94272 |
