| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PP1 | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-264666 |
| PPP1CB | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-248577 |
| PPP1CC | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-248504 |
| PPP1CA | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-248566 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PP1 | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-264666 |
| PPP1CB | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-248577 |
| PPP1CC | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-248504 |
| PPP1CA | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-248566 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PP1 | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-264666 |
| PPP1CB | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-248577 |
| PPP1CC | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-248504 |
| PPP1CA | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-248566 |