| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CB | MDM2 | Thr216 | RSSSSEStGTPSNPD | dephosphorylation up-regulates | 11983168 | SIGNOR-86736 |
| PPP2CA | MDM2 | Thr216 | RSSSSEStGTPSNPD | dephosphorylation up-regulates activity | 11983168 | SIGNOR-248636 |
| PPP2CB | MDM2 | Thr216 | RSSSSEStGTPSNPD | dephosphorylation up-regulates activity | 11983168 | SIGNOR-248593 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CB | dephosphorylation down-regulates ⊣ | MDM2 PThr216 | dephosphorylation down-regulates ⊣ | MDM2 | 11983168 | SIGNOR-86736 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MDM2 PThr216 | dephosphorylation down-regulates ⊣ | MDM2 | 11983168 | SIGNOR-248636 |
| PPP2CB | dephosphorylation down-regulates ⊣ | MDM2 PThr216 | dephosphorylation down-regulates ⊣ | MDM2 | 11983168 | SIGNOR-248593 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CB | dephosphorylation → up-regulates | MDM2 | SIGNOR-86736 |
| PPP2CA | dephosphorylation → up-regulates activity | MDM2 | SIGNOR-248636 |
| PPP2CB | dephosphorylation → up-regulates activity | MDM2 | SIGNOR-248593 |
