| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GTF2H1 | E2F1 | Thr433 | DCDFGDLtPLDF | phosphorylation down-regulates quantity by destabilization | 10428966 | SIGNOR-251260 |
| CHEK2 | E2F1 | Ser364 | PLLSRMGsLRAPVDE | phosphorylation up-regulates activity | 12717439 | SIGNOR-260822 |
| CDK7 | E2F1 | Thr433 | DCDFGDLtPLDF | phosphorylation down-regulates | 10428966 | SIGNOR-69780 |
| CKM complex | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates activity | 22945643 | SIGNOR-273138 |
| ERK1/2 | E2F1 | – | phosphorylation up-regulates activity | 23616010 | SIGNOR-233526 | |
| PRKACA | E2F1 | Thr130 | GEKSRYEtSLNLTTK | phosphorylation up-regulates activity | 33110360 | SIGNOR-277536 |
| MAPK3 | E2F1 | – | phosphorylation up-regulates | 14967450 | SIGNOR-121991 | |
| TFIIH | E2F1 | Thr433 | DCDFGDLtPLDF | phosphorylation down-regulates | 10428966 | SIGNOR-269354 |
| CHEK2 | E2F1 | Ser364 | PLLSRMGsLRAPVDE | phosphorylation up-regulates quantity by stabilization | 12717439 | SIGNOR-100898 |
| MAPK3 | E2F1 | – | phosphorylation up-regulates | 22802261 | SIGNOR-198292 | |
| CDK1 | E2F1 | Ser332 | TDSATIVsPPPSSPP | phosphorylation up-regulates | 8087847 | SIGNOR-36022 |
| CDK8 | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates | 18794899 | SIGNOR-181078 |
| PRKACA | E2F1 | Ser364 | PLLSRMGsLRAPVDE | phosphorylation up-regulates activity | 33110360 | SIGNOR-277537 |
| GTF2H1 | E2F1 | Ser403 | PEEFISLsPPHEALD | phosphorylation down-regulates quantity by destabilization | 10428966 | SIGNOR-251259 |
| CDK8 | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates | 22945643 | SIGNOR-198934 |
| CDK7 | E2F1 | Ser403 | PEEFISLsPPHEALD | phosphorylation down-regulates | 10428966 | SIGNOR-69776 |
| CDK1 | E2F1 | Ser337 | IVSPPPSsPPSSLTT | phosphorylation up-regulates | 8087847 | SIGNOR-36026 |
| TFIIH | E2F1 | Ser403 | PEEFISLsPPHEALD | phosphorylation down-regulates | 10428966 | SIGNOR-269353 |
| PRKACA | E2F1 | Ser235 | TTQLRLLsEDTDSQR | phosphorylation up-regulates activity | 33110360 | SIGNOR-277538 |
| MAPK8 | E2F1 | – | phosphorylation down-regulates activity | 10075927 | SIGNOR-279218 | |
| CKM complex | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates activity | 18794899 | SIGNOR-273149 |
| CHEK2 | E2F1 | Ser364 | PLLSRMGsLRAPVDE | phosphorylation up-regulates quantity by stabilization | 22558186 | SIGNOR-197278 |
| ATM | E2F1 | Ser31 | ALRLLDSsQIVIISA | phosphorylation up-regulates quantity by stabilization | 11459832 | SIGNOR-109416 |
| ATR | E2F1 | Ser31 | ALRLLDSsQIVIISA | phosphorylation up-regulates quantity by stabilization | 11459832 | SIGNOR-109420 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GTF2H1 | phosphorylation up-regulates → | E2F1 PThr433 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-251260 |
| CHEK2 | phosphorylation up-regulates → | E2F1 PSer364 | phosphorylation up-regulates → | E2F1 | 12717439 | SIGNOR-260822 |
| CDK7 | phosphorylation up-regulates → | E2F1 PThr433 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-69780 |
| CKM complex | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 22945643 | SIGNOR-273138 |
| PRKACA | phosphorylation up-regulates → | E2F1 PThr130 | phosphorylation up-regulates → | E2F1 | 33110360 | SIGNOR-277536 |
| TFIIH | phosphorylation up-regulates → | E2F1 PThr433 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-269354 |
| CHEK2 | phosphorylation up-regulates → | E2F1 PSer364 | phosphorylation up-regulates → | E2F1 | 12717439 | SIGNOR-100898 |
| CDK1 | phosphorylation up-regulates → | E2F1 PSer332 | phosphorylation up-regulates → | E2F1 | 8087847 | SIGNOR-36022 |
| CDK8 | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 18794899 | SIGNOR-181078 |
| PRKACA | phosphorylation up-regulates → | E2F1 PSer364 | phosphorylation up-regulates → | E2F1 | 33110360 | SIGNOR-277537 |
| GTF2H1 | phosphorylation up-regulates → | E2F1 PSer403 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-251259 |
| CDK8 | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 22945643 | SIGNOR-198934 |
| CDK7 | phosphorylation up-regulates → | E2F1 PSer403 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-69776 |
| CDK1 | phosphorylation up-regulates → | E2F1 PSer337 | phosphorylation up-regulates → | E2F1 | 8087847 | SIGNOR-36026 |
| TFIIH | phosphorylation up-regulates → | E2F1 PSer403 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-269353 |
| PRKACA | phosphorylation up-regulates → | E2F1 PSer235 | phosphorylation up-regulates → | E2F1 | 33110360 | SIGNOR-277538 |
| CKM complex | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 18794899 | SIGNOR-273149 |
| CHEK2 | phosphorylation up-regulates → | E2F1 PSer364 | phosphorylation up-regulates → | E2F1 | 22558186 | SIGNOR-197278 |
| ATM | phosphorylation up-regulates → | E2F1 PSer31 | phosphorylation up-regulates → | E2F1 | 11459832 | SIGNOR-109416 |
| ATR | phosphorylation up-regulates → | E2F1 PSer31 | phosphorylation up-regulates → | E2F1 | 11459832 | SIGNOR-109420 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GTF2H1 | phosphorylation down-regulates quantity by destabilization | E2F1 | SIGNOR-251260 |
| CHEK2 | phosphorylation → up-regulates activity | E2F1 | SIGNOR-260822 |
| CDK7 | phosphorylation down-regulates | E2F1 | SIGNOR-69780 |
| CKM complex | phosphorylation → down-regulates activity | E2F1 | SIGNOR-273138 |
| ERK1/2 | phosphorylation → up-regulates activity | E2F1 | SIGNOR-233526 |
| PRKACA | phosphorylation → up-regulates activity | E2F1 | SIGNOR-277536 |
| MAPK3 | phosphorylation → up-regulates | E2F1 | SIGNOR-121991 |
| TFIIH | phosphorylation down-regulates | E2F1 | SIGNOR-269354 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | E2F1 | SIGNOR-100898 |
| MAPK3 | phosphorylation → up-regulates | E2F1 | SIGNOR-198292 |
| CDK1 | phosphorylation → up-regulates | E2F1 | SIGNOR-36022 |
| CDK8 | phosphorylation down-regulates | E2F1 | SIGNOR-181078 |
| PRKACA | phosphorylation → up-regulates activity | E2F1 | SIGNOR-277537 |
| GTF2H1 | phosphorylation down-regulates quantity by destabilization | E2F1 | SIGNOR-251259 |
| CDK8 | phosphorylation down-regulates | E2F1 | SIGNOR-198934 |
| CDK7 | phosphorylation down-regulates | E2F1 | SIGNOR-69776 |
| CDK1 | phosphorylation → up-regulates | E2F1 | SIGNOR-36026 |
| TFIIH | phosphorylation down-regulates | E2F1 | SIGNOR-269353 |
| PRKACA | phosphorylation → up-regulates activity | E2F1 | SIGNOR-277538 |
| MAPK8 | phosphorylation → down-regulates activity | E2F1 | SIGNOR-279218 |
| CKM complex | phosphorylation → down-regulates activity | E2F1 | SIGNOR-273149 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | E2F1 | SIGNOR-197278 |
| ATM | phosphorylation → up-regulates quantity by stabilization | E2F1 | SIGNOR-109416 |
| ATR | phosphorylation → up-regulates quantity by stabilization | E2F1 | SIGNOR-109420 |
