Summary

Name E2F1
Full Name Transcription factor E2F1
Synonyms E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1, Retinoblastoma-binding protein 3, RBBP-3, pRB-binding protein E2F-1 | RBBP3
Primary ID Q01094
Links - -
Type protein
Relations 59
Pathways Cell cycle: G1/S phase transition, Malignant Melanoma, Luminal Breast Cancer
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation E2F1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Cell cycle: G1/S phase transition
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation E2F1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Cell cycle: G1/S phase transition
+ up-regulates img/direct-activation.png phosphorylation E2F1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation E2F1 0.34
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ down-regulates img/direct_inhibition.png phosphorylation E2F1 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation E2F1 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation E2F1 0.14
Publications: 2 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TLR3 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TYMS 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MUC4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HDAC1 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding E2F1 0.22
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HIC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MT1G 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation E2F1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTNND2 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png G1/S transition 0.54
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Luminal Breast Cancer, Malignant Melanoma
+ down-regulates img/indirect_inhibition.png E2F1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding E2F1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation E2F1 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SMAD7/HDAC1/E2F-1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding E2F1 0.72
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Luminal Breast Cancer, Malignant Melanoma
+ up-regulates img/direct-activation.png phosphorylation E2F1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ELF4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png transcriptional regulation CDK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TFDP1 0.42
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png phosphorylation E2F1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer, Malignant Melanoma
+ up-regulates img/indirect-activation.png transcriptional regulation PPARG 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD2AP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ISYNA1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ATM 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ up-regulates activity img/direct-activation.png binding E2F1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCNE1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation E2F1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CyclinE/CDK2 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ up-regulates img/direct-activation.png binding E2F1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BBC3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDC25A 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DHFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RRM1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding E2F1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HSPA5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LRBA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MCPH1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYBL2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOX4 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCNA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RASGEF1B 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RASGRP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SERPINB5 0.14
Publications: 1 Organism: Homo Sapiens