| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK8 | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates | 18794899 | SIGNOR-181078 |
| CDK8 | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates | 22945643 | SIGNOR-198934 |
| CKM complex | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates activity | 18794899 | SIGNOR-273149 |
| CKM complex | E2F1 | Ser375 | PVDEDRLsPLVAADS | phosphorylation down-regulates activity | 22945643 | SIGNOR-273138 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK8 | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 18794899 | SIGNOR-181078 |
| CDK8 | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 22945643 | SIGNOR-198934 |
| CKM complex | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 18794899 | SIGNOR-273149 |
| CKM complex | phosphorylation up-regulates → | E2F1 PSer375 | phosphorylation down-regulates ⊣ | E2F1 | 22945643 | SIGNOR-273138 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK8 | phosphorylation down-regulates | E2F1 | SIGNOR-181078 |
| CDK8 | phosphorylation down-regulates | E2F1 | SIGNOR-198934 |
| CKM complex | phosphorylation → down-regulates activity | E2F1 | SIGNOR-273149 |
| CKM complex | phosphorylation → down-regulates activity | E2F1 | SIGNOR-273138 |
