| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GTF2H1 | E2F1 | Thr433 | DCDFGDLtPLDF | phosphorylation down-regulates quantity by destabilization | 10428966 | SIGNOR-251260 |
| CDK7 | E2F1 | Thr433 | DCDFGDLtPLDF | phosphorylation down-regulates | 10428966 | SIGNOR-69780 |
| TFIIH | E2F1 | Thr433 | DCDFGDLtPLDF | phosphorylation down-regulates | 10428966 | SIGNOR-269354 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GTF2H1 | phosphorylation up-regulates → | E2F1 PThr433 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-251260 |
| CDK7 | phosphorylation up-regulates → | E2F1 PThr433 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-69780 |
| TFIIH | phosphorylation up-regulates → | E2F1 PThr433 | phosphorylation down-regulates ⊣ | E2F1 | 10428966 | SIGNOR-269354 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GTF2H1 | phosphorylation down-regulates quantity by destabilization | E2F1 | SIGNOR-251260 |
| CDK7 | phosphorylation down-regulates | E2F1 | SIGNOR-69780 |
| TFIIH | phosphorylation down-regulates | E2F1 | SIGNOR-269354 |
