| Name | MEF2A |
| ID | Q02078 |
| Role | substrate |
| Enzymatic Domains |
MADS-box 3-57 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | MEF2A | Thr319 | TPVVSVTtPSLPPQG | phosphorylation up-regulates | 9858528 | SIGNOR-62784 |
| MAPK14 | MEF2A | Ser453 | PRQEMGRsPVDSLSS | phosphorylation unknown | 12586839 | SIGNOR-98228 |
| MAPK7 | MEF2A | Thr312 | QATQPLAtPVVSVTT | phosphorylation up-regulates | 10849446 | SIGNOR-236583 |
| CDK5 | MEF2A | Ser408 | SIKSEPIsPPRDRMT | phosphorylation down-regulates activity | 12691662 | SIGNOR-100574 |
| MAPK7 | MEF2A | Thr319 | TPVVSVTtPSLPPQG | phosphorylation up-regulates | 10849446 | SIGNOR-236579 |
| MAPK14 | MEF2A | Thr312 | QATQPLAtPVVSVTT | phosphorylation up-regulates activity | 9858528 | SIGNOR-62780 |
| MAPK7 | MEF2A | Ser355 | SALQGFNsPGMLSLG | phosphorylation up-regulates | 10849446 | SIGNOR-236587 |
| PKCtheta/Nfix | MEF2A | – | phosphorylation up-regulates activity | 20178747 | SIGNOR-238022 | |
| MAPK14 | MEF2A | Ser408 | SIKSEPIsPPRDRMT | phosphorylation unknown | 12586839 | SIGNOR-98224 |
| MAPK11 | MEF2A | – | phosphorylation up-regulates activity | 10330143 | SIGNOR-280024 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | phosphorylation up-regulates → | MEF2A PThr319 | phosphorylation up-regulates → | MEF2A | 9858528 | SIGNOR-62784 |
| MAPK14 | phosphorylation up-regulates → | MEF2A PSer453 | phosphorylation down-regulates ⊣ | MEF2A | 12586839 | SIGNOR-98228 |
| MAPK7 | phosphorylation up-regulates → | MEF2A PThr312 | phosphorylation up-regulates → | MEF2A | 10849446 | SIGNOR-236583 |
| CDK5 | phosphorylation up-regulates → | MEF2A PSer408 | phosphorylation down-regulates ⊣ | MEF2A | 12691662 | SIGNOR-100574 |
| MAPK7 | phosphorylation up-regulates → | MEF2A PThr319 | phosphorylation up-regulates → | MEF2A | 10849446 | SIGNOR-236579 |
| MAPK14 | phosphorylation up-regulates → | MEF2A PThr312 | phosphorylation up-regulates → | MEF2A | 9858528 | SIGNOR-62780 |
| MAPK7 | phosphorylation up-regulates → | MEF2A PSer355 | phosphorylation up-regulates → | MEF2A | 10849446 | SIGNOR-236587 |
| MAPK14 | phosphorylation up-regulates → | MEF2A PSer408 | phosphorylation down-regulates ⊣ | MEF2A | 12586839 | SIGNOR-98224 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → up-regulates | MEF2A | SIGNOR-62784 |
| MAPK14 | phosphorylation → unknown | MEF2A | SIGNOR-98228 |
| MAPK7 | phosphorylation → up-regulates | MEF2A | SIGNOR-236583 |
| CDK5 | phosphorylation → down-regulates activity | MEF2A | SIGNOR-100574 |
| MAPK7 | phosphorylation → up-regulates | MEF2A | SIGNOR-236579 |
| MAPK14 | phosphorylation → up-regulates activity | MEF2A | SIGNOR-62780 |
| MAPK7 | phosphorylation → up-regulates | MEF2A | SIGNOR-236587 |
| PKCtheta/Nfix | phosphorylation → up-regulates activity | MEF2A | SIGNOR-238022 |
| MAPK14 | phosphorylation → unknown | MEF2A | SIGNOR-98224 |
| MAPK11 | phosphorylation → up-regulates activity | MEF2A | SIGNOR-280024 |