Summary

Name MEF2A
Full Name Myocyte-specific enhancer factor 2A
Synonyms Serum response factor-like protein 1 | MEF2
Primary ID Q02078
Links - -
Type protein
Relations 26
Pathways IGF and Myogenesis, P38 Signaling, P38 Signaling and Myogenesis
Function Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation MEF2A 0.74
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MEF2A 0.37
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MEF2A 0.23
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation MEF2A 0.23
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation MEF2A 0.23
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding MEF2A 0.35
Publications: 1 Organism: Mus Musculus
Tissue: Myotube
+ up-regulates activity img/direct-activation.png phosphorylation MEF2A
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding MEF2A 0.80
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYF6 0.65
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png binding MYOD1 0.41
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH1 0.45
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH10 0.64
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png binding MEF2A 0.41
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH2 0.36
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ down-regulates img/indirect_inhibition.png unknown MEF2A 0.62
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown Myoblast fusion
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/indirect-activation.png unknown MEF2A 0.64
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png methylation MEF2A 0.47
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png binding MEF2A 0.37
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png binding MEF2A
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png binding MEF2A 0.86
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png binding MEF2A 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MEF2A 0.63
Publications: 1 Organism: Mus Musculus
Tissue: Muscle