| Name | PRKCE |
| ID | Q02156 |
| Role | substrate |
| Enzymatic Domains |
C2 1-117 PROSITE-ProRule
Protein kinase 408-668 PROSITE-ProRule
AGC-kinase C-terminal 669-737 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDPK1 | PRKCE | Thr566 | LNGVTTTtFCGTPDY | phosphorylation up-regulates | 11964154 | SIGNOR-117320 |
| GSK3B | PRKCE | Ser346 | SEEDRSKsAPTSPCD | phosphorylation up-regulates | 18604201 | SIGNOR-179412 |
| mTORC2 | PRKCE | Thr710 | TREEPVLtLVDEAIV | phosphorylation up-regulates activity | 21806543 | SIGNOR-276347 |
| PRKCE | PRKCE | Ser729 | QEEFKGFsYFGEDLM | phosphorylation down-regulates | 11964154 | SIGNOR-117324 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDPK1 | phosphorylation up-regulates → | PRKCE PThr566 | phosphorylation up-regulates → | PRKCE | 11964154 | SIGNOR-117320 |
| GSK3B | phosphorylation up-regulates → | PRKCE PSer346 | phosphorylation up-regulates → | PRKCE | 18604201 | SIGNOR-179412 |
| mTORC2 | phosphorylation up-regulates → | PRKCE PThr710 | phosphorylation up-regulates → | PRKCE | 21806543 | SIGNOR-276347 |
| PRKCE | phosphorylation up-regulates → | PRKCE PSer729 | phosphorylation down-regulates ⊣ | PRKCE | 11964154 | SIGNOR-117324 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDPK1 | phosphorylation → up-regulates | PRKCE | SIGNOR-117320 |
| GSK3B | phosphorylation → up-regulates | PRKCE | SIGNOR-179412 |
| mTORC2 | phosphorylation → up-regulates activity | PRKCE | SIGNOR-276347 |
| PRKCE | phosphorylation down-regulates | PRKCE | SIGNOR-117324 |