| Name | MECOM |
| ID | Q03112 |
| Role | substrate |
| Enzymatic Domains |
SET 78-190 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | MECOM | Ser1037 | IGNSNHGsQSPRNVE | phosphorylation up-regulates activity | 23858473 | SIGNOR-273427 |
| ATM | MECOM | Ser1039 | NSNHGSQsPRNVEER | phosphorylation up-regulates activity | 29939287 | SIGNOR-273434 |
| CSNK2A1 | MECOM | Ser726 | PLKMEPQsPGEVKKL | phosphorylation up-regulates activity | 23858473 | SIGNOR-273428 |
| PPP1CA | MECOM | Ser1037 | IGNSNHGsQSPRNVE | dephosphorylation down-regulates activity | 23858473 | SIGNOR-273429 |
| PPP1CA | MECOM | Ser726 | PLKMEPQsPGEVKKL | dephosphorylation down-regulates activity | 23858473 | SIGNOR-273430 |
| CDK2 | MECOM | Ser624 | KMFKDKVsPLQNLAS | phosphorylation up-regulates activity | 33082307 | SIGNOR-273426 |
| ATM | MECOM | Ser1037 | IGNSNHGsQSPRNVE | phosphorylation up-regulates activity | 29939287 | SIGNOR-273433 |
| CDK3 | MECOM | Ser624 | KMFKDKVsPLQNLAS | phosphorylation up-regulates activity | 33082307 | SIGNOR-273431 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | MECOM PSer1037 | phosphorylation up-regulates → | MECOM | 23858473 | SIGNOR-273427 |
| ATM | phosphorylation up-regulates → | MECOM PSer1039 | phosphorylation up-regulates → | MECOM | 29939287 | SIGNOR-273434 |
| CSNK2A1 | phosphorylation up-regulates → | MECOM PSer726 | phosphorylation up-regulates → | MECOM | 23858473 | SIGNOR-273428 |
| PPP1CA | dephosphorylation down-regulates ⊣ | MECOM PSer1037 | dephosphorylation up-regulates → | MECOM | 23858473 | SIGNOR-273429 |
| PPP1CA | dephosphorylation down-regulates ⊣ | MECOM PSer726 | dephosphorylation up-regulates → | MECOM | 23858473 | SIGNOR-273430 |
| CDK2 | phosphorylation up-regulates → | MECOM PSer624 | phosphorylation up-regulates → | MECOM | 33082307 | SIGNOR-273426 |
| ATM | phosphorylation up-regulates → | MECOM PSer1037 | phosphorylation up-regulates → | MECOM | 29939287 | SIGNOR-273433 |
| CDK3 | phosphorylation up-regulates → | MECOM PSer624 | phosphorylation up-regulates → | MECOM | 33082307 | SIGNOR-273431 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → up-regulates activity | MECOM | SIGNOR-273427 |
| ATM | phosphorylation → up-regulates activity | MECOM | SIGNOR-273434 |
| CSNK2A1 | phosphorylation → up-regulates activity | MECOM | SIGNOR-273428 |
| PPP1CA | dephosphorylation → down-regulates activity | MECOM | SIGNOR-273429 |
| PPP1CA | dephosphorylation → down-regulates activity | MECOM | SIGNOR-273430 |
| CDK2 | phosphorylation → up-regulates activity | MECOM | SIGNOR-273426 |
| ATM | phosphorylation → up-regulates activity | MECOM | SIGNOR-273433 |
| CDK3 | phosphorylation → up-regulates activity | MECOM | SIGNOR-273431 |