Summary

Name MECOM
Full Name MDS1 and EVI1 complex locus protein EVI1
Synonyms Ecotropic virus integration site 1 protein homolog, EVI-1 | EVI1
Primary ID Q03112
Links - -
Type protein
Relations 5
Pathways Acute Myeloid Leukemia, MLL in AML
Function Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation MECOM 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL in AML
+ up-regulates quantity by expression img/direct-activation.png methylation MECOM 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PBX1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RUNX1 0.4
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL in AML
+ down-regulates img/direct_inhibition.png binding SMAD3 0.36
Publications: 1 Organism: Homo Sapiens