| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | MECOM | Ser726 | PLKMEPQsPGEVKKL | phosphorylation up-regulates activity | 23858473 | SIGNOR-273428 |
| PPP1CA | MECOM | Ser726 | PLKMEPQsPGEVKKL | dephosphorylation down-regulates activity | 23858473 | SIGNOR-273430 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | MECOM PSer726 | phosphorylation up-regulates → | MECOM | 23858473 | SIGNOR-273428 |
| PPP1CA | dephosphorylation down-regulates ⊣ | MECOM PSer726 | dephosphorylation up-regulates → | MECOM | 23858473 | SIGNOR-273430 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → up-regulates activity | MECOM | SIGNOR-273428 |
| PPP1CA | dephosphorylation → down-regulates activity | MECOM | SIGNOR-273430 |