| Name | RELA |
| ID | Q04206 |
| Role | substrate |
| Enzymatic Domains |
RHD 19-306 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | RELA | Ser468 | AVFTDLAsVDNSEFQ | phosphorylation up-regulates | 16407239 | SIGNOR-143581 |
| PPP4C | RELA | Thr435 | PTQAGEGtLSEALLQ | dephosphorylation up-regulates activity | 15073167 | SIGNOR-248549 |
| CHUK | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 10521409 | SIGNOR-71270 |
| CSN1S1 | RELA | Ser529 | GLPNGLLsGDEDFSS | phosphorylation up-regulates | 21232017 | SIGNOR-171222 |
| PPM1A | RELA | Ser276 | SMQLRRPsDRELSEP | dephosphorylation down-regulates activity | 23812431 | SIGNOR-276963 |
| PAK5 | RELA | – | phosphorylation up-regulates activity | 29041983 | SIGNOR-275657 | |
| CSNK2A1 | RELA | Ser543 | SIADMDFsALLSQIS | phosphorylation up-regulates activity | 10938077 | SIGNOR-250942 |
| GSK3B | RELA | Ser468 | AVFTDLAsVDNSEFQ | phosphorylation up-regulates | 17183360 | SIGNOR-151422 |
| IKBKB | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15489227 | SIGNOR-129935 |
| PPM1A | RELA | Ser536 | SGDEDFSsIADMDFS | dephosphorylation down-regulates activity | 23812431 | SIGNOR-276964 |
| ATM | RELA | Ser547 | MDFSALLsQISS | phosphorylation down-regulates activity | 24957606 | SIGNOR-279006 |
| CHUK | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15489227 | SIGNOR-129931 |
| PRKCZ | RELA | Ser311 | RTYETFKsIMKKSPF | phosphorylation up-regulates | 17183360 | SIGNOR-151432 |
| IKBKE | RELA | Ser468 | AVFTDLAsVDNSEFQ | phosphorylation up-regulates | 15489227 | SIGNOR-129939 |
| IKBKG | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15489227 | SIGNOR-129947 |
| PPP2CA | RELA | – | dephosphorylation down-regulates | 11591705 | SIGNOR-110959 | |
| IKBKB | RELA | Ser468 | AVFTDLAsVDNSEFQ | phosphorylation up-regulates activity | 16046471 | SIGNOR-138903 |
| GSK3A | RELA | Thr254 | RQVAIVFRtPPYADPS | phosphorylation up-regulates activity | 22761446 | SIGNOR-255827 |
| CSNK2A1 | RELA | Ser529 | GLPNGLLsGDEDFSS | phosphorylation up-regulates activity | 10938077 | SIGNOR-149635 |
| TBK1 | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates | 15489227 | SIGNOR-129951 |
| CSNK1A1 | RELA | Ser316 | FKSIMKKsPFSGPTD | phosphorylation up-regulates activity | 26082493 | SIGNOR-276916 |
| GSK3B | RELA | Thr254 | RQVAIVFRtPPYADPS | phosphorylation up-regulates activity | 22761446 | SIGNOR-255828 |
| PRKACA | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 9660950 | SIGNOR-58972 |
| PIM | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 19911008 | SIGNOR-259411 |
| RPS6KA5 | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 12628924 | SIGNOR-99210 |
| RPS6KA4 | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 17183360 | SIGNOR-151436 |
| IKBKE | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates | 15489227 | SIGNOR-129943 |
| PIM1 | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 19911008 | SIGNOR-189125 |
| CHUK | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15611276 | SIGNOR-132568 |
| BTK | RELA | – | phosphorylation up-regulates activity | 26018652 | SIGNOR-280197 | |
| CHEK1 | RELA | Thr505 | EAITRLVtGAQRPPD | phosphorylation up-regulates activity | 15775976 | SIGNOR-280225 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | RELA PSer468 | phosphorylation up-regulates → | RELA | 16407239 | SIGNOR-143581 |
| PPP4C | dephosphorylation down-regulates ⊣ | RELA PThr435 | dephosphorylation down-regulates ⊣ | RELA | 15073167 | SIGNOR-248549 |
| CHUK | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 10521409 | SIGNOR-71270 |
| CSN1S1 | phosphorylation up-regulates → | RELA PSer529 | phosphorylation up-regulates → | RELA | 21232017 | SIGNOR-171222 |
| PPM1A | dephosphorylation down-regulates ⊣ | RELA PSer276 | dephosphorylation up-regulates → | RELA | 23812431 | SIGNOR-276963 |
| CSNK2A1 | phosphorylation up-regulates → | RELA PSer543 | phosphorylation up-regulates → | RELA | 10938077 | SIGNOR-250942 |
| GSK3B | phosphorylation up-regulates → | RELA PSer468 | phosphorylation up-regulates → | RELA | 17183360 | SIGNOR-151422 |
| IKBKB | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129935 |
| PPM1A | dephosphorylation down-regulates ⊣ | RELA PSer536 | dephosphorylation up-regulates → | RELA | 23812431 | SIGNOR-276964 |
| ATM | phosphorylation up-regulates → | RELA PSer547 | phosphorylation down-regulates ⊣ | RELA | 24957606 | SIGNOR-279006 |
| CHUK | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129931 |
| PRKCZ | phosphorylation up-regulates → | RELA PSer311 | phosphorylation up-regulates → | RELA | 17183360 | SIGNOR-151432 |
| IKBKE | phosphorylation up-regulates → | RELA PSer468 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129939 |
| IKBKG | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129947 |
| IKBKB | phosphorylation up-regulates → | RELA PSer468 | phosphorylation up-regulates → | RELA | 16046471 | SIGNOR-138903 |
| GSK3A | phosphorylation up-regulates → | RELA PThr254 | phosphorylation up-regulates → | RELA | 22761446 | SIGNOR-255827 |
| CSNK2A1 | phosphorylation up-regulates → | RELA PSer529 | phosphorylation up-regulates → | RELA | 10938077 | SIGNOR-149635 |
| TBK1 | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129951 |
| CSNK1A1 | phosphorylation up-regulates → | RELA PSer316 | phosphorylation up-regulates → | RELA | 26082493 | SIGNOR-276916 |
| GSK3B | phosphorylation up-regulates → | RELA PThr254 | phosphorylation up-regulates → | RELA | 22761446 | SIGNOR-255828 |
| PRKACA | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 9660950 | SIGNOR-58972 |
| PIM | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 19911008 | SIGNOR-259411 |
| RPS6KA5 | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 12628924 | SIGNOR-99210 |
| RPS6KA4 | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 17183360 | SIGNOR-151436 |
| IKBKE | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129943 |
| PIM1 | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 19911008 | SIGNOR-189125 |
| CHUK | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15611276 | SIGNOR-132568 |
| CHEK1 | phosphorylation up-regulates → | RELA PThr505 | phosphorylation up-regulates → | RELA | 15775976 | SIGNOR-280225 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → up-regulates | RELA | SIGNOR-143581 |
| PPP4C | dephosphorylation → up-regulates activity | RELA | SIGNOR-248549 |
| CHUK | phosphorylation → up-regulates activity | RELA | SIGNOR-71270 |
| CSN1S1 | phosphorylation → up-regulates | RELA | SIGNOR-171222 |
| PPM1A | dephosphorylation → down-regulates activity | RELA | SIGNOR-276963 |
| PAK5 | phosphorylation → up-regulates activity | RELA | SIGNOR-275657 |
| CSNK2A1 | phosphorylation → up-regulates activity | RELA | SIGNOR-250942 |
| GSK3B | phosphorylation → up-regulates | RELA | SIGNOR-151422 |
| IKBKB | phosphorylation → up-regulates activity | RELA | SIGNOR-129935 |
| PPM1A | dephosphorylation → down-regulates activity | RELA | SIGNOR-276964 |
| ATM | phosphorylation → down-regulates activity | RELA | SIGNOR-279006 |
| CHUK | phosphorylation → up-regulates activity | RELA | SIGNOR-129931 |
| PRKCZ | phosphorylation → up-regulates | RELA | SIGNOR-151432 |
| IKBKE | phosphorylation → up-regulates | RELA | SIGNOR-129939 |
| IKBKG | phosphorylation → up-regulates activity | RELA | SIGNOR-129947 |
| PPP2CA | dephosphorylation down-regulates | RELA | SIGNOR-110959 |
| IKBKB | phosphorylation → up-regulates activity | RELA | SIGNOR-138903 |
| GSK3A | phosphorylation → up-regulates activity | RELA | SIGNOR-255827 |
| CSNK2A1 | phosphorylation → up-regulates activity | RELA | SIGNOR-149635 |
| TBK1 | phosphorylation → up-regulates | RELA | SIGNOR-129951 |
| CSNK1A1 | phosphorylation → up-regulates activity | RELA | SIGNOR-276916 |
| GSK3B | phosphorylation → up-regulates activity | RELA | SIGNOR-255828 |
| PRKACA | phosphorylation → up-regulates | RELA | SIGNOR-58972 |
| PIM | phosphorylation → up-regulates | RELA | SIGNOR-259411 |
| RPS6KA5 | phosphorylation → up-regulates | RELA | SIGNOR-99210 |
| RPS6KA4 | phosphorylation → up-regulates | RELA | SIGNOR-151436 |
| IKBKE | phosphorylation → up-regulates | RELA | SIGNOR-129943 |
| PIM1 | phosphorylation → up-regulates | RELA | SIGNOR-189125 |
| CHUK | phosphorylation → up-regulates activity | RELA | SIGNOR-132568 |
| BTK | phosphorylation → up-regulates activity | RELA | SIGNOR-280197 |
| CHEK1 | phosphorylation → up-regulates activity | RELA | SIGNOR-280225 |