Summary

Name RELA
Full Name Transcription factor p65
Synonyms Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 | NFKB3
Primary ID Q04206
Links - -
Type protein
Relations 63
Function NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png methylation RELA 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png demethylation RELA 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png demethylation RELA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deacetylation RELA 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png acetylation RELA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RELA 0.64
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.23
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RELA 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RELA 0.51
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RELA 0.3
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RELA 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation RELA 0.23
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation RELA 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IEX-1L 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RELA 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RELA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RELA 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation MET 0.22
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation RELA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RELA 0.5
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RELA 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRAF2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CITED1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation RELA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png transcriptional regulation IL1B 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation COMT 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PCK2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL1B 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CREBBP 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RELA 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png transcriptional regulation NPPB 0.14
Publications: 1
+ down-regulates img/direct_inhibition.png binding RELA 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD80 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2A1 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SNAIL/RELA/PARP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation B2M 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBP/p300 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation RELA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HDAC4 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding NfKb-p65/p50 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation RELA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGR1 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding REL/RELA 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney