| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHUK | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 10521409 | SIGNOR-71270 |
| IKBKB | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15489227 | SIGNOR-129935 |
| PPM1A | RELA | Ser536 | SGDEDFSsIADMDFS | dephosphorylation down-regulates activity | 23812431 | SIGNOR-276964 |
| CHUK | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15489227 | SIGNOR-129931 |
| IKBKG | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15489227 | SIGNOR-129947 |
| TBK1 | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates | 15489227 | SIGNOR-129951 |
| IKBKE | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates | 15489227 | SIGNOR-129943 |
| CHUK | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15611276 | SIGNOR-132568 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHUK | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 10521409 | SIGNOR-71270 |
| IKBKB | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129935 |
| PPM1A | dephosphorylation down-regulates ⊣ | RELA PSer536 | dephosphorylation up-regulates → | RELA | 23812431 | SIGNOR-276964 |
| CHUK | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129931 |
| IKBKG | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129947 |
| TBK1 | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129951 |
| IKBKE | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129943 |
| CHUK | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15611276 | SIGNOR-132568 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHUK | phosphorylation → up-regulates activity | RELA | SIGNOR-71270 |
| IKBKB | phosphorylation → up-regulates activity | RELA | SIGNOR-129935 |
| PPM1A | dephosphorylation → down-regulates activity | RELA | SIGNOR-276964 |
| CHUK | phosphorylation → up-regulates activity | RELA | SIGNOR-129931 |
| IKBKG | phosphorylation → up-regulates activity | RELA | SIGNOR-129947 |
| TBK1 | phosphorylation → up-regulates | RELA | SIGNOR-129951 |
| IKBKE | phosphorylation → up-regulates | RELA | SIGNOR-129943 |
| CHUK | phosphorylation → up-regulates activity | RELA | SIGNOR-132568 |
