| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | RELA | Ser276 | SMQLRRPsDRELSEP | dephosphorylation down-regulates activity | 23812431 | SIGNOR-276963 |
| RPS6KA5 | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 12628924 | SIGNOR-99210 |
| RPS6KA4 | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 17183360 | SIGNOR-151436 |
| PRKACA | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 9660950 | SIGNOR-58972 |
| PIM | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 19911008 | SIGNOR-259411 |
| PIM1 | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 19911008 | SIGNOR-189125 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | dephosphorylation down-regulates ⊣ | RELA PSer276 | dephosphorylation up-regulates → | RELA | 23812431 | SIGNOR-276963 |
| RPS6KA5 | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 12628924 | SIGNOR-99210 |
| RPS6KA4 | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 17183360 | SIGNOR-151436 |
| PRKACA | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 9660950 | SIGNOR-58972 |
| PIM | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 19911008 | SIGNOR-259411 |
| PIM1 | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 19911008 | SIGNOR-189125 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1A | dephosphorylation → down-regulates activity | RELA | SIGNOR-276963 |
| RPS6KA5 | phosphorylation → up-regulates | RELA | SIGNOR-99210 |
| RPS6KA4 | phosphorylation → up-regulates | RELA | SIGNOR-151436 |
| PRKACA | phosphorylation → up-regulates | RELA | SIGNOR-58972 |
| PIM | phosphorylation → up-regulates | RELA | SIGNOR-259411 |
| PIM1 | phosphorylation → up-regulates | RELA | SIGNOR-189125 |
