| Name | ACVR1 |
| ID | Q04771 |
| Role | kinase |
| Enzymatic Domains |
GS 178-207 PROSITE-ProRule
Protein kinase 208-502 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ACVR1 | SMAD1 | – | phosphorylation up-regulates | 9748228 | SIGNOR-60174 | |
| ACVR1 | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates activity | 9748228 | SIGNOR-247674 |
| ACVR1 | SMAD1 | Ser465 | HNPISSVs | phosphorylation up-regulates activity | 9748228 | SIGNOR-251439 |
| ACVR1 | SMAD5 | – | phosphorylation up-regulates | 9748228 | SIGNOR-60171 | |
| ACVR1 | AMOT/MPP5/INADL/LIN7C | – | phosphorylation up-regulates | 9748228 | SIGNOR-210093 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ACVR1 | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9748228 | SIGNOR-247674 |
| ACVR1 | phosphorylation up-regulates → | SMAD1 PSer465 | phosphorylation up-regulates → | SMAD1 | 9748228 | SIGNOR-251439 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ACVR1 | phosphorylation → up-regulates | SMAD1 | SIGNOR-60174 |
| ACVR1 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-247674 |
| ACVR1 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-251439 |
| ACVR1 | phosphorylation → up-regulates | SMAD5 | SIGNOR-60171 |
| ACVR1 | phosphorylation → up-regulates | AMOT/MPP5/INADL/LIN7C | SIGNOR-210093 |