4.0
Summary
| Name |  ACVR1View Modifications |
| Full Name | Activin receptor type-1 |
| Synonyms | Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I | ACVRLK2 |
| Primary ID | Q04771 |
| Links |  -  -  |
| Type | protein |
| Relations | 16 |
| Inhibitors | 4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ACVR1 | up-regulates activity 
phosphorylation
|
SMAD1 | 0.704 |
| Publications: | 2 | Organism: | Mus Musculus, Chlorocebus Aethiops | |
| + | TGFBR1 | up-regulates activity
phosphorylation
|
ACVR1 | 0.362 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BMP7 | up-regulates
binding
|
ACVR1 | 0.808 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | ACVR1 | up-regulates
phosphorylation
|
AMOT/MPP5/INADL/LIN7C | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ACVR1 | up-regulates
phosphorylation
|
SMAD1 | 0.704 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ACVR1 | down-regulates activity 
|
AKT | 0.248 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ACVR1 | up-regulates 
|
SMAD5 | 0.76 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | ACVR1 | up-regulates
phosphorylation
|
SMAD5 | 0.76 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ACVR1 | form complex 
binding
|
ACVR1/BMPR2 | 0.713 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ACVR2A | up-regulates
binding
|
ACVR1 | 0.664 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ACVR1 | down-regulates activity
|
AKT1 | 0.248 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AMHR2 | up-regulates
binding
|
ACVR1 | 0.554 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BMPR2 | up-regulates
binding
|
ACVR1 | 0.713 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ACVR1 | up-regulates activity
binding
|
VPS39 | 0.2 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | 4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline | down-regulates 
chemical inhibition
|
ACVR1 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |