Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PTPN12	PSTPIP1	Tyr345	PERNEGVyTAIAVQE	dephosphorylation down-regulates activity	11711533	SIGNOR-248656
PTPN12	JAK2	–		dephosphorylation down-regulates	11731619	SIGNOR-112383
PTPN12	JAK2	Tyr1007	VLPQDKEyYKVKEPG	dephosphorylation down-regulates activity	11731619	SIGNOR-248657
PTPN12	JAK2	Tyr1008	LPQDKEYyKVKEPGE	dephosphorylation down-regulates activity	11731619	SIGNOR-248658
PTPN12	ABL1	Tyr393	RLMTGDTyTAHAGAK	dephosphorylation down-regulates activity	11163214	SIGNOR-235568
PTPN12	ABL1	–		dephosphorylation down-regulates activity	11163214	SIGNOR-246222
PTPN12	ERBB2	Tyr1196	GAVENPEyLTPQGGA	dephosphorylation down-regulates activity	29330094	SIGNOR-277038
PTPN12	INSR	Tyr1185	FGMTRDIyETDYYRK	dephosphorylation down-regulates	10734133	SIGNOR-75894
PTPN12	INSR	Tyr1189	RDIYETDyYRKGGKG	dephosphorylation down-regulates	10734133	SIGNOR-75898
PTPN12	INSR	Tyr1190	DIYETDYyRKGGKGL	dephosphorylation down-regulates	10734133	SIGNOR-262291
PTPN12	INSR	Tyr1190	DIYETDYyRKGGKGL	dephosphorylation down-regulates	10734133	SIGNOR-75902
PTPN12	INSR	Tyr999	YASSNPEyLSASDVF	dephosphorylation down-regulates	10734133	SIGNOR-75906
PTPN12	INSR	Tyr1185	FGMTRDIyETDYYRK	dephosphorylation down-regulates	8454633	SIGNOR-39147
PTPN12	INSR	Tyr1189	RDIYETDyYRKGGKG	dephosphorylation down-regulates	8454633	SIGNOR-39151
PTPN12	INSR	Tyr999	YASSNPEyLSASDVF	dephosphorylation down-regulates	8454633	SIGNOR-39159
PTPN12	INSR	–		dephosphorylation down-regulates	8454633	SIGNOR-39155
PTPN12	SRC	Tyr419	RLIEDNEyTARQGAK	dephosphorylation down-regulates activity	18482983	SIGNOR-248659
PTPN12	SRC	Tyr530	FTSTEPQyQPGENL	dephosphorylation up-regulates activity	19350555	SIGNOR-277086
PTPN12	SHC1	Tyr349	EEPPDHQyYNDFPGK	dephosphorylation down-regulates	8939605	SIGNOR-44361
PTPN12	SHC1	Tyr350	EPPDHQYyNDFPGKE	dephosphorylation down-regulates	8939605	SIGNOR-44862
PTPN12	WAS	–		dephosphorylation down-regulates	11711533	SIGNOR-111688
PTPN12	WAS	–		dephosphorylation down-regulates	14707117	SIGNOR-121136
PTPN12	WAS	Tyr291	AETSKLIyDFIEDQG	dephosphorylation down-regulates activity	14707117	SIGNOR-248660
PTPN12	ARHGDIA	–		dephosphorylation up-regulates activity	25666508	SIGNOR-277175
PTPN12	BCAR1	–		dephosphorylation down-regulates	11432829	SIGNOR-109032
PTPN12	PTK2	–		dephosphorylation down-regulates	11432829	SIGNOR-109035
PTPN12	PTK2	Tyr397	SVSETDDyAEIIDEE	dephosphorylation down-regulates activity	19595712	SIGNOR-248661
PTPN12	GIT2	Tyr286	EELAMDVyDEVDRRE	dephosphorylation down-regulates	16317044	SIGNOR-142711
PTPN12	GIT2	Tyr392	QDNDQPDyDSVASDE	dephosphorylation down-regulates	16317044	SIGNOR-142715
PTPN12	GIT2	Tyr592	NSTPESDyDNTPNDM	dephosphorylation down-regulates	16317044	SIGNOR-142719
PTPN12	PTK2B	Tyr402	CSIESDIyAEIPDET	dephosphorylation down-regulates activity	11337490	SIGNOR-248662
PTPN12	PTK2B	Tyr579	RYIEDEDyYKASVTR	dephosphorylation down-regulates activity	11337490	SIGNOR-107502
PTPN12	PTK2B	Tyr580	YIEDEDYyKASVTRL	dephosphorylation down-regulates activity	11337490	SIGNOR-248664

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PTPN12	dephosphorylation down-regulates ⊣	PSTPIP1 PTyr345	dephosphorylation up-regulates →	PSTPIP1	11711533	SIGNOR-248656
PTPN12	dephosphorylation down-regulates ⊣	JAK2 PTyr1007	dephosphorylation up-regulates →	JAK2	11731619	SIGNOR-248657
PTPN12	dephosphorylation down-regulates ⊣	JAK2 PTyr1008	dephosphorylation up-regulates →	JAK2	11731619	SIGNOR-248658
PTPN12	dephosphorylation down-regulates ⊣	ABL1 PTyr393	dephosphorylation up-regulates →	ABL1	11163214	SIGNOR-235568
PTPN12	dephosphorylation down-regulates ⊣	ERBB2 PTyr1196	dephosphorylation up-regulates →	ERBB2	29330094	SIGNOR-277038
PTPN12	dephosphorylation down-regulates ⊣	INSR PTyr1185	dephosphorylation up-regulates →	INSR	10734133	SIGNOR-75894
PTPN12	dephosphorylation down-regulates ⊣	INSR PTyr1189	dephosphorylation up-regulates →	INSR	10734133	SIGNOR-75898
PTPN12	dephosphorylation down-regulates ⊣	INSR PTyr1190	dephosphorylation up-regulates →	INSR	10734133	SIGNOR-262291
PTPN12	dephosphorylation down-regulates ⊣	INSR PTyr1190	dephosphorylation up-regulates →	INSR	10734133	SIGNOR-75902
PTPN12	dephosphorylation down-regulates ⊣	INSR PTyr999	dephosphorylation up-regulates →	INSR	10734133	SIGNOR-75906
PTPN12	dephosphorylation down-regulates ⊣	INSR PTyr1185	dephosphorylation up-regulates →	INSR	8454633	SIGNOR-39147
PTPN12	dephosphorylation down-regulates ⊣	INSR PTyr1189	dephosphorylation up-regulates →	INSR	8454633	SIGNOR-39151
PTPN12	dephosphorylation down-regulates ⊣	INSR PTyr999	dephosphorylation up-regulates →	INSR	8454633	SIGNOR-39159
PTPN12	dephosphorylation down-regulates ⊣	SRC PTyr419	dephosphorylation up-regulates →	SRC	18482983	SIGNOR-248659
PTPN12	dephosphorylation down-regulates ⊣	SRC PTyr530	dephosphorylation down-regulates ⊣	SRC	19350555	SIGNOR-277086
PTPN12	dephosphorylation down-regulates ⊣	SHC1 PTyr349	dephosphorylation up-regulates →	SHC1	8939605	SIGNOR-44361
PTPN12	dephosphorylation down-regulates ⊣	SHC1 PTyr350	dephosphorylation up-regulates →	SHC1	8939605	SIGNOR-44862
PTPN12	dephosphorylation down-regulates ⊣	WAS PTyr291	dephosphorylation up-regulates →	WAS	14707117	SIGNOR-248660
PTPN12	dephosphorylation down-regulates ⊣	PTK2 PTyr397	dephosphorylation up-regulates →	PTK2	19595712	SIGNOR-248661
PTPN12	dephosphorylation down-regulates ⊣	GIT2 PTyr286	dephosphorylation up-regulates →	GIT2	16317044	SIGNOR-142711
PTPN12	dephosphorylation down-regulates ⊣	GIT2 PTyr392	dephosphorylation up-regulates →	GIT2	16317044	SIGNOR-142715
PTPN12	dephosphorylation down-regulates ⊣	GIT2 PTyr592	dephosphorylation up-regulates →	GIT2	16317044	SIGNOR-142719
PTPN12	dephosphorylation down-regulates ⊣	PTK2B PTyr402	dephosphorylation up-regulates →	PTK2B	11337490	SIGNOR-248662
PTPN12	dephosphorylation down-regulates ⊣	PTK2B PTyr579	dephosphorylation up-regulates →	PTK2B	11337490	SIGNOR-107502
PTPN12	dephosphorylation down-regulates ⊣	PTK2B PTyr580	dephosphorylation up-regulates →	PTK2B	11337490	SIGNOR-248664

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PTPN12	dephosphorylation → down-regulates activity	PSTPIP1	SIGNOR-248656
PTPN12	dephosphorylation down-regulates	JAK2	SIGNOR-112383
PTPN12	dephosphorylation → down-regulates activity	JAK2	SIGNOR-248657
PTPN12	dephosphorylation → down-regulates activity	JAK2	SIGNOR-248658
PTPN12	dephosphorylation → down-regulates activity	ABL1	SIGNOR-235568
PTPN12	dephosphorylation → down-regulates activity	ABL1	SIGNOR-246222
PTPN12	dephosphorylation → down-regulates activity	ERBB2	SIGNOR-277038
PTPN12	dephosphorylation down-regulates	INSR	SIGNOR-75894
PTPN12	dephosphorylation down-regulates	INSR	SIGNOR-75898
PTPN12	dephosphorylation down-regulates	INSR	SIGNOR-262291
PTPN12	dephosphorylation down-regulates	INSR	SIGNOR-75902
PTPN12	dephosphorylation down-regulates	INSR	SIGNOR-75906
PTPN12	dephosphorylation down-regulates	INSR	SIGNOR-39147
PTPN12	dephosphorylation down-regulates	INSR	SIGNOR-39151
PTPN12	dephosphorylation down-regulates	INSR	SIGNOR-39159
PTPN12	dephosphorylation down-regulates	INSR	SIGNOR-39155
PTPN12	dephosphorylation → down-regulates activity	SRC	SIGNOR-248659
PTPN12	dephosphorylation → up-regulates activity	SRC	SIGNOR-277086
PTPN12	dephosphorylation down-regulates	SHC1	SIGNOR-44361
PTPN12	dephosphorylation down-regulates	SHC1	SIGNOR-44862
PTPN12	dephosphorylation down-regulates	WAS	SIGNOR-111688
PTPN12	dephosphorylation down-regulates	WAS	SIGNOR-121136
PTPN12	dephosphorylation → down-regulates activity	WAS	SIGNOR-248660
PTPN12	dephosphorylation → up-regulates activity	ARHGDIA	SIGNOR-277175
PTPN12	dephosphorylation down-regulates	BCAR1	SIGNOR-109032
PTPN12	dephosphorylation down-regulates	PTK2	SIGNOR-109035
PTPN12	dephosphorylation → down-regulates activity	PTK2	SIGNOR-248661
PTPN12	dephosphorylation down-regulates	GIT2	SIGNOR-142711
PTPN12	dephosphorylation down-regulates	GIT2	SIGNOR-142715
PTPN12	dephosphorylation down-regulates	GIT2	SIGNOR-142719
PTPN12	dephosphorylation → down-regulates activity	PTK2B	SIGNOR-248662
PTPN12	dephosphorylation → down-regulates activity	PTK2B	SIGNOR-107502
PTPN12	dephosphorylation → down-regulates activity	PTK2B	SIGNOR-248664