Summary

Name PTPN12
Full Name Tyrosine-protein phosphatase non-receptor type 12
Synonyms PTP-PEST, Protein-tyrosine phosphatase G1, PTPG1
Primary ID Q05209
Links - -
Type protein
Relations 31
Function Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation PTPN12 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation JAK2 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.2
Publications: 8 Organism: Homo Sapiens, In Vitro
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png dephosphorylation GIT2 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation WAS 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PSTPIP1 0.31
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation SHC1 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ABL1 0.14
Publications: 2 Organism: Chlorocebus Aethiops, Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTK2 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTK2B 0.34
Publications: 3 Organism: Rattus Norvegicus, Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation WAS 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation JAK2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png dephosphorylation PTK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation BCAR1 0.22
Publications: 1 Organism: Homo Sapiens