| Name | PTPN12 |
| ID | Q05209 |
| Role | substrate |
| Enzymatic Domains |
Tyrosine-protein phosphatase 28-293 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK24 | PTPN12 | – | phosphorylation down-regulates activity | 26910843 | SIGNOR-279127 | |
| CDK2 | PTPN12 | Ser19 | QRVQAMKsPDHNGED | phosphorylation down-regulates activity | 28842430 | SIGNOR-277366 |
| PRKCA | PTPN12 | Ser435 | KKLERNLsFEIKKVP | phosphorylation down-regulates | 7520867 | SIGNOR-27304 |
| PRKCA | PTPN12 | Ser39 | FMRLRRLsTKYRTEK | phosphorylation down-regulates | 7520867 | SIGNOR-27300 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | PTPN12 PSer19 | phosphorylation down-regulates ⊣ | PTPN12 | 28842430 | SIGNOR-277366 |
| PRKCA | phosphorylation up-regulates → | PTPN12 PSer435 | phosphorylation down-regulates ⊣ | PTPN12 | 7520867 | SIGNOR-27304 |
| PRKCA | phosphorylation up-regulates → | PTPN12 PSer39 | phosphorylation down-regulates ⊣ | PTPN12 | 7520867 | SIGNOR-27300 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK24 | phosphorylation → down-regulates activity | PTPN12 | SIGNOR-279127 |
| CDK2 | phosphorylation → down-regulates activity | PTPN12 | SIGNOR-277366 |
| PRKCA | phosphorylation down-regulates | PTPN12 | SIGNOR-27304 |
| PRKCA | phosphorylation down-regulates | PTPN12 | SIGNOR-27300 |