| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| Gbeta | LIPE | – | phosphorylation up-regulates activity | 11581251 | SIGNOR-270119 | |
| PRKACA | LIPE | Ser951 | GFHPRRSsQGATQMP | phosphorylation up-regulates activity | 11581251 | SIGNOR-249204 |
| PRKACA | LIPE | Ser853 | IAEPMRRsVSEAALA | phosphorylation up-regulates activity | 11581251 | SIGNOR-249202 |
| ERK1/2 | LIPE | – | phosphorylation up-regulates activity | 11581251 | SIGNOR-270207 | |
| PKA | LIPE | Ser951 | GFHPRRSsQGATQMP | phosphorylation up-regulates activity | 19018281 | SIGNOR-276175 |
| PRKAA1 | LIPE | Ser855 | EPMRRSVsEAALAQP | phosphorylation down-regulates | 9636039 | SIGNOR-58255 |
| CAMK2A | LIPE | Ser855 | EPMRRSVsEAALAQP | phosphorylation down-regulates | 9636039 | SIGNOR-58251 |
| PKA | LIPE | Ser950 | EGFHPRRsSQGATQM | phosphorylation up-regulates activity | 19018281 | SIGNOR-276174 |
| PRKACA | LIPE | Ser950 | EGFHPRRsSQGATQM | phosphorylation up-regulates activity | 11581251 | SIGNOR-249203 |
| MAPK1 | LIPE | Thr891 | NSETSSDtPEMSLSA | phosphorylation up-regulates activity | 11581251 | SIGNOR-249413 |
| MAPK3 | LIPE | Thr891 | NSETSSDtPEMSLSA | phosphorylation up-regulates activity | 11581251 | SIGNOR-249470 |
| PRKACA | LIPE | Ser855 | EPMRRSVsEAALAQP | phosphorylation down-regulates | 9636039 | SIGNOR-58259 |
| AMPK | LIPE | Ser855 | EPMRRSVsEAALAQP | phosphorylation down-regulates | 9636039 | SIGNOR-216507 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | LIPE PSer951 | phosphorylation up-regulates → | LIPE | 11581251 | SIGNOR-249204 |
| PRKACA | phosphorylation up-regulates → | LIPE PSer853 | phosphorylation up-regulates → | LIPE | 11581251 | SIGNOR-249202 |
| PKA | phosphorylation up-regulates → | LIPE PSer951 | phosphorylation up-regulates → | LIPE | 19018281 | SIGNOR-276175 |
| PRKAA1 | phosphorylation up-regulates → | LIPE PSer855 | phosphorylation down-regulates ⊣ | LIPE | 9636039 | SIGNOR-58255 |
| CAMK2A | phosphorylation up-regulates → | LIPE PSer855 | phosphorylation down-regulates ⊣ | LIPE | 9636039 | SIGNOR-58251 |
| PKA | phosphorylation up-regulates → | LIPE PSer950 | phosphorylation up-regulates → | LIPE | 19018281 | SIGNOR-276174 |
| PRKACA | phosphorylation up-regulates → | LIPE PSer950 | phosphorylation up-regulates → | LIPE | 11581251 | SIGNOR-249203 |
| MAPK1 | phosphorylation up-regulates → | LIPE PThr891 | phosphorylation up-regulates → | LIPE | 11581251 | SIGNOR-249413 |
| MAPK3 | phosphorylation up-regulates → | LIPE PThr891 | phosphorylation up-regulates → | LIPE | 11581251 | SIGNOR-249470 |
| PRKACA | phosphorylation up-regulates → | LIPE PSer855 | phosphorylation down-regulates ⊣ | LIPE | 9636039 | SIGNOR-58259 |
| AMPK | phosphorylation up-regulates → | LIPE PSer855 | phosphorylation down-regulates ⊣ | LIPE | 9636039 | SIGNOR-216507 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| Gbeta | phosphorylation → up-regulates activity | LIPE | SIGNOR-270119 |
| PRKACA | phosphorylation → up-regulates activity | LIPE | SIGNOR-249204 |
| PRKACA | phosphorylation → up-regulates activity | LIPE | SIGNOR-249202 |
| ERK1/2 | phosphorylation → up-regulates activity | LIPE | SIGNOR-270207 |
| PKA | phosphorylation → up-regulates activity | LIPE | SIGNOR-276175 |
| PRKAA1 | phosphorylation down-regulates | LIPE | SIGNOR-58255 |
| CAMK2A | phosphorylation down-regulates | LIPE | SIGNOR-58251 |
| PKA | phosphorylation → up-regulates activity | LIPE | SIGNOR-276174 |
| PRKACA | phosphorylation → up-regulates activity | LIPE | SIGNOR-249203 |
| MAPK1 | phosphorylation → up-regulates activity | LIPE | SIGNOR-249413 |
| MAPK3 | phosphorylation → up-regulates activity | LIPE | SIGNOR-249470 |
| PRKACA | phosphorylation down-regulates | LIPE | SIGNOR-58259 |
| AMPK | phosphorylation down-regulates | LIPE | SIGNOR-216507 |
