| Name | PRKCD |
| ID | Q05655 |
| Role | substrate |
| Enzymatic Domains |
C2 1-106 PROSITE-ProRule
Protein kinase 349-603 PROSITE-ProRule
AGC-kinase C-terminal 604-675 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | PRKCD | – | dephosphorylation down-regulates | 11350745 | SIGNOR-107754 | |
| AKT1 | PRKCD | – | phosphorylation up-regulates activity | 25247763 | SIGNOR-280175 | |
| ABL1 | PRKCD | Tyr155 | IKQAKIHyIKNHEFI | phosphorylation up-regulates activity | 28637715 | SIGNOR-279436 |
| PPP2CA | PRKCD | Ser645 | LNEKARLsYSDKNLI | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248638 |
| FER | PRKCD | Tyr374 | ELKGRGEyFAIKALK | phosphorylation up-regulates activity | 33411917 | SIGNOR-277546 |
| SRC | PRKCD | Tyr334 | MQDNSGTyGKIWEGS | phosphorylation up-regulates activity | 17658731 | SIGNOR-278164 |
| FYN | PRKCD | Tyr313 | SSEPVGIyQGFEKKT | phosphorylation up-regulates activity | 33995031 | SIGNOR-279737 |
| LYN | PRKCD | Tyr567 | IRVDTPHyPRWITKE | phosphorylation down-regulates activity | 11812791 | SIGNOR-251407 |
| LCK | PRKCD | Tyr514 | TFCGTPDyIAPEILQ | phosphorylation up-regulates activity | 11381116 | SIGNOR-251386 |
| LCK | PRKCD | Tyr334 | MQDNSGTyGKIWEGS | phosphorylation up-regulates activity | 11381116 | SIGNOR-251385 |
| PPP2CB | PRKCD | Ser664 | QSAFAGFsFVNPKFE | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248596 |
| PRKCD | PRKCD | Ser302 | TQRASRRsDSASSEP | phosphorylation unknown | 19366211 | SIGNOR-185291 |
| PRKCD | PRKCD | Ser645 | LNEKARLsYSDKNLI | phosphorylation up-regulates | 15731106 | SIGNOR-134207 |
| PRKCD | PRKCD | Ser299 | NQVTQRAsRRSDSAS | phosphorylation up-regulates | 17603046 | SIGNOR-156523 |
| PPP2CB | PRKCD | Thr507 | FGESRAStFCGTPDY | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248594 |
| PPP2CA | PRKCD | Thr507 | FGESRAStFCGTPDY | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248637 |
| PRKCD | PRKCD | Thr295 | AEALNQVtQRASRRS | phosphorylation up-regulates | 19366211 | SIGNOR-185283 |
| PTPRC | PRKCD | – | dephosphorylation down-regulates activity | 11124968 | SIGNOR-277028 | |
| PRKCD | PRKCD | Ser645 | LNEKARLsYSDKNLI | phosphorylation up-regulates | 9305920 | SIGNOR-51000 |
| PRKCD | PRKCD | Thr218 | TAANSRDtIFQKERF | phosphorylation unknown | 19366211 | SIGNOR-185303 |
| LYN | PRKCD | Tyr52 | VQKKPTMyPEWKSTF | phosphorylation up-regulates activity | 9692543 | SIGNOR-251408 |
| PRKCD | PRKCD | Ser304 | RASRRSDsASSEPVG | phosphorylation unknown | 19366211 | SIGNOR-185295 |
| PRKCD | PRKCD | Thr141 | EDEAKFPtMNRRGAI | phosphorylation up-regulates | 19366211 | SIGNOR-185279 |
| PRKCD | PRKCD | Thr507 | FGESRAStFCGTPDY | phosphorylation up-regulates | 19366211 | SIGNOR-185287 |
| PDPK1 | PRKCD | Thr507 | FGESRAStFCGTPDY | phosphorylation up-regulates activity | 9748166 | SIGNOR-250269 |
| PPP2CA | PRKCD | Ser664 | QSAFAGFsFVNPKFE | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248639 |
| LCK | PRKCD | Tyr313 | SSEPVGIyQGFEKKT | phosphorylation up-regulates activity | 11381116 | SIGNOR-251384 |
| PRKCD | PRKCD | Ser503 | KENIFGEsRASTFCG | phosphorylation unknown | 19366211 | SIGNOR-185299 |
| PPP2CB | PRKCD | Ser645 | LNEKARLsYSDKNLI | dephosphorylation down-regulates activity | 11959144 | SIGNOR-248595 |
| PTPRG | PRKCD | Tyr313 | SSEPVGIyQGFEKKT | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254716 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | PRKCD PTyr155 | phosphorylation up-regulates → | PRKCD | 28637715 | SIGNOR-279436 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCD PSer645 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248638 |
| FER | phosphorylation up-regulates → | PRKCD PTyr374 | phosphorylation up-regulates → | PRKCD | 33411917 | SIGNOR-277546 |
| SRC | phosphorylation up-regulates → | PRKCD PTyr334 | phosphorylation up-regulates → | PRKCD | 17658731 | SIGNOR-278164 |
| FYN | phosphorylation up-regulates → | PRKCD PTyr313 | phosphorylation up-regulates → | PRKCD | 33995031 | SIGNOR-279737 |
| LYN | phosphorylation up-regulates → | PRKCD PTyr567 | phosphorylation down-regulates ⊣ | PRKCD | 11812791 | SIGNOR-251407 |
| LCK | phosphorylation up-regulates → | PRKCD PTyr514 | phosphorylation up-regulates → | PRKCD | 11381116 | SIGNOR-251386 |
| LCK | phosphorylation up-regulates → | PRKCD PTyr334 | phosphorylation up-regulates → | PRKCD | 11381116 | SIGNOR-251385 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCD PSer664 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248596 |
| PRKCD | phosphorylation up-regulates → | PRKCD PSer302 | phosphorylation down-regulates ⊣ | PRKCD | 19366211 | SIGNOR-185291 |
| PRKCD | phosphorylation up-regulates → | PRKCD PSer645 | phosphorylation up-regulates → | PRKCD | 15731106 | SIGNOR-134207 |
| PRKCD | phosphorylation up-regulates → | PRKCD PSer299 | phosphorylation up-regulates → | PRKCD | 17603046 | SIGNOR-156523 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCD PThr507 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248594 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCD PThr507 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248637 |
| PRKCD | phosphorylation up-regulates → | PRKCD PThr295 | phosphorylation up-regulates → | PRKCD | 19366211 | SIGNOR-185283 |
| PRKCD | phosphorylation up-regulates → | PRKCD PSer645 | phosphorylation up-regulates → | PRKCD | 9305920 | SIGNOR-51000 |
| PRKCD | phosphorylation up-regulates → | PRKCD PThr218 | phosphorylation down-regulates ⊣ | PRKCD | 19366211 | SIGNOR-185303 |
| LYN | phosphorylation up-regulates → | PRKCD PTyr52 | phosphorylation up-regulates → | PRKCD | 9692543 | SIGNOR-251408 |
| PRKCD | phosphorylation up-regulates → | PRKCD PSer304 | phosphorylation down-regulates ⊣ | PRKCD | 19366211 | SIGNOR-185295 |
| PRKCD | phosphorylation up-regulates → | PRKCD PThr141 | phosphorylation up-regulates → | PRKCD | 19366211 | SIGNOR-185279 |
| PRKCD | phosphorylation up-regulates → | PRKCD PThr507 | phosphorylation up-regulates → | PRKCD | 19366211 | SIGNOR-185287 |
| PDPK1 | phosphorylation up-regulates → | PRKCD PThr507 | phosphorylation up-regulates → | PRKCD | 9748166 | SIGNOR-250269 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PRKCD PSer664 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248639 |
| LCK | phosphorylation up-regulates → | PRKCD PTyr313 | phosphorylation up-regulates → | PRKCD | 11381116 | SIGNOR-251384 |
| PRKCD | phosphorylation up-regulates → | PRKCD PSer503 | phosphorylation down-regulates ⊣ | PRKCD | 19366211 | SIGNOR-185299 |
| PPP2CB | dephosphorylation down-regulates ⊣ | PRKCD PSer645 | dephosphorylation up-regulates → | PRKCD | 11959144 | SIGNOR-248595 |
| PTPRG | dephosphorylation down-regulates ⊣ | PRKCD PTyr313 | dephosphorylation down-regulates ⊣ | PRKCD | 25624455 | SIGNOR-254716 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates | PRKCD | SIGNOR-107754 |
| AKT1 | phosphorylation → up-regulates activity | PRKCD | SIGNOR-280175 |
| ABL1 | phosphorylation → up-regulates activity | PRKCD | SIGNOR-279436 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248638 |
| FER | phosphorylation → up-regulates activity | PRKCD | SIGNOR-277546 |
| SRC | phosphorylation → up-regulates activity | PRKCD | SIGNOR-278164 |
| FYN | phosphorylation → up-regulates activity | PRKCD | SIGNOR-279737 |
| LYN | phosphorylation → down-regulates activity | PRKCD | SIGNOR-251407 |
| LCK | phosphorylation → up-regulates activity | PRKCD | SIGNOR-251386 |
| LCK | phosphorylation → up-regulates activity | PRKCD | SIGNOR-251385 |
| PPP2CB | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248596 |
| PRKCD | phosphorylation → unknown | PRKCD | SIGNOR-185291 |
| PRKCD | phosphorylation → up-regulates | PRKCD | SIGNOR-134207 |
| PRKCD | phosphorylation → up-regulates | PRKCD | SIGNOR-156523 |
| PPP2CB | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248594 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248637 |
| PRKCD | phosphorylation → up-regulates | PRKCD | SIGNOR-185283 |
| PTPRC | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-277028 |
| PRKCD | phosphorylation → up-regulates | PRKCD | SIGNOR-51000 |
| PRKCD | phosphorylation → unknown | PRKCD | SIGNOR-185303 |
| LYN | phosphorylation → up-regulates activity | PRKCD | SIGNOR-251408 |
| PRKCD | phosphorylation → unknown | PRKCD | SIGNOR-185295 |
| PRKCD | phosphorylation → up-regulates | PRKCD | SIGNOR-185279 |
| PRKCD | phosphorylation → up-regulates | PRKCD | SIGNOR-185287 |
| PDPK1 | phosphorylation → up-regulates activity | PRKCD | SIGNOR-250269 |
| PPP2CA | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248639 |
| LCK | phosphorylation → up-regulates activity | PRKCD | SIGNOR-251384 |
| PRKCD | phosphorylation → unknown | PRKCD | SIGNOR-185299 |
| PPP2CB | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-248595 |
| PTPRG | dephosphorylation → up-regulates activity | PRKCD | SIGNOR-254716 |