Summary

Name PRKCD
Full Name Protein kinase C delta type
Synonyms Tyrosine-protein kinase PRKCD, 2.7.10.2, nPKC-delta
Primary ID Q05655
Links - -
Type protein
Relations 141
Inhibitors bisindolylmaleimide i
Function Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.22
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KLF5 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PEBP1 0.08
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MARCKS 0.08
Publications: 3 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CHN2 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SDC4 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation G6PD 0.08
Publications: 2 Organism: Homo Sapiens
Tissue: Smooth Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation TAGLN 0.08
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation BAG3 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPRA 0.08
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ELAVL1 0.37
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TNNI3 0.08
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ADRA2A 0.08
Publications: 1 Organism: Cricetulus Griseus
+ img/unknown.png phosphorylation DAB2 0.08
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation DAB2 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ADRB2 0.08
Publications: 4 Organism: In Vitro
+ img/unknown.png phosphorylation GNAZ 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MYBPC3 0.08
Publications: 3 Organism: Homo Sapiens
Tissue: Heart
+ img/unknown.png phosphorylation SHC1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LIMK2 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP73 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRK2 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCD 0.20
Publications: 6 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PRKCD 0.08
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPK 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.39
Publications: 8 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.22
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ down-regulates img/direct_inhibition.png phosphorylation C5AR1 0.18
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation OPRD1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PTPN22 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PA2G4 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BDKRB2 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FSCN1 0.08
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CYTH1 0.08
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NFE2L2 0.08
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation CREBBP 0.08
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation HMGA1 0.08
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.32
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RPS6KB2 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TRIM28 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ENOX2 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMPD1 0.08
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EIF2S1 0.08
Publications: 1 Organism: In Vitro
+ up-regulates quantity img/direct-activation.png phosphorylation CHAT 0.08
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation YWHAZ 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS3 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation YWHAB 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DNM1L 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PRKCD 0.08
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PRKCD 0.08
Publications: 3 Organism: Mus Musculus
+ img/unknown.png phosphorylation ADD2 0.08
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKD1 0.08
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ITGB2 0.08
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NR2F6 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.08
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation EP300 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MUC1 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TNNI3 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NCF4 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLSCR1 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation PLSCR3 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DAP3 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FLI1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HABP4 0.08
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DBI 0.08
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EEF1A1 0.08
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation HIST1H3A 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS3 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKCD 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLD2 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.08
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation ITGB2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ITGB2 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ITGB7 0.08
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation IL6ST 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IL6ST 0.08
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png dephosphorylation PRKCD 0.08
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PRKCD 0.08
Publications: 3 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation PRKCD 0.08
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKCD 0.08
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation PRKCD 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png IRS1 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png binding PRKCD 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png KCNJ1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PRKCD 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK8 0.22
Publications: 1 Organism: Homo Sapiens